Cat. No. 3048
Chemical Name: (2E)-3-[(4S,7R,7aR)-2,4,5,6,7,7a-He
Biological ActivityPositive allosteric modulator of GABAA receptors that displays preference for receptors containing β2 or β3 subunits. Directly activates the receptor and blocks the channel at high concentrations. Displays sedative, anticonvulsant and anxiolytic activity in vivo. Also acts as a partial agonist of 5-HT5A receptors.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Khom et al (2016) Analysis of β-subunit-dependent GABAA receptor modulation and behavioral effects of valerenic acid derivatives. J.Pharmacol.Exp.Ther. 357 580. PMID: 27190170.
Benke et al (2008) GABAA receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts. Neuropharmacology 56 174. PMID: 18602406.
Khom et al (2007) Valerenic acid potentiates and inhibits GABAA receptors: molecular mechanism and subunit specificity. Neuropharmacol. 53 178. PMID: 17585957.
Dietz et al (2005) Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro. Brain Res.Mol.Brain Res. 138 191. PMID: 15921820.
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Keywords: Valerenic acid, supplier, Positive, allosteric, modulators, GABAA, receptors, Receptors, Tocris Bioscience, GABAA Receptor Modulator products