Cat. No. 1305
Chemical Name: 1,2,3,4-Tetrahydro-4-(3-hydroxyphen
Biological ActivityPotent, cell-permeable, small molecule mitosis inhibitor that does not interact with tubulin. Arrests cells in mitosis and specifically inhibits the motility of the mitotic kinesin Eg5, a motor protein required for mitotic spindle formation and maintenance (IC50 = 14 μM).
Licensing InformationSold with the permission of Harvard University
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Kapoor et al (2000) Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5. J.Cell Biol. 150 975. PMID: 10973989.
Mayer et al (1999) Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science 286 971. PMID: 10542155.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for Monastrol include:
Shrestha and Draviam (2013) Lateral to end-on conversion of chromosome-microtubule attachment requires kinesins CENP-E and MCAK. Curr Biol 23 1514. PMID: 23891108.
Lera and Burkard (2012) High mitotic activity of Polo-like kinase 1 is required for chromosome segregation and genomic integrity in human epithelial cells. J Biol Chem 287 42812. PMID: 23105120.
Samoshkin et al (2009) Human condensin function is essential for centromeric chromatin assembly and proper sister kinetochore orientation. PLoS One 4 e6831. PMID: 19714251.
Trinkle-Mulcahy et al (2003) Time-lapse imaging reveals dynamic relocalization of PP1gamma throughout the mammalian cell cycle. Mol Biol Cell 14 107. PMID: 12529430.
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Keywords: Monastrol, supplier, Selective, inhibitors, inhibits, mitotic, kinesin, Eg5, Mitosis, Tocris Bioscience, Kinesin Inhibitor products