Cat. No. 3046
Chemical Name: (3α,5α)-3-Hydroxypregnane-11,20-dione
Biological ActivityA neurosteroid anesthetic that directly activates and potentiates GABAA receptor-activated membrane current (IGABA). Efficacy but not potency is determined by the alpha subunit of the receptor (EC50 values are 1.4, 1.8, 2.1, 2.4 and 2.5 μM for α1β1γ3, α1β1γ1, β1γ1, α2β1γ2L and α1β1γ2L isoforms respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Zecharia et al (2009) The involvement of hypothalamic sleep pathways in general anesthesia: Testing the hypothesis using the GABAA receptor β3N265M knock-in mouse. J.Neurosci. 29 2177. PMID: 19228970.
Wegner et al (2007) Auto-modulation of neuroactive steroids on GABAA receptors: a novel pharmacological effect. Neuropharmacology. 52 672. PMID: 17084864.
Maitra et al (1999) Subunit dependent modulation of GABAA receptor function by neuroactive steroids. Brain Res. 819 75. PMID: 10082863.
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Keywords: Alphaxalone, supplier, Direct, activators, potentiator, GABAA, Receptors, Tocris Bioscience, GABAA Receptor Modulator products