Cat. No. 0826

 C10H16N8S2 [69014-14-8]

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Alternative Name: ICI 125,211

Biological Activity

Potent histamine H2-receptor antagonist with negligible activity against H1- and H3- receptors.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

Soluble to 10 mM in ethanol and to 100 mM in DMSO
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Hill (1990) Distribution, properties, and functional characteristics of three classes of histamine receptor. Pharmacol.Rev. 42 45. PMID: 2164693.

Trzeciakowski and Levi (1980) The cardiac pharmacology of tiotidine (ICI 125,211): A new histamine H2- receptor antagonist. J.Pharmacol.Exp.Ther. 214 629. PMID: 6105207.

Yellin et al (1979) ICI 125,211: A new gastric antisecretory agent acting on histamine H2- receptors. Life Sci. 25 2001. PMID: 43449.

If you know of a relevant reference for Tiotidine please let us know.

Citations are publications that use Tocris products. Selected citations for Tiotidine include:

Alonso et al (2015) Physiological implications of biased signaling at histamine H2 receptors. Exp Ther Med 6 45. PMID: 25805997.

Holden et al (2007) Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. Front Pharmacol 152 891. PMID: 17891168.

Do you know of a great paper that uses Tiotidine from Tocris? If so please let us know.

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Keywords: Tiotidine, supplier, Potent, selective, H2, antagonists, Receptors, Histamine, histaminergic, AstraZeneca, ICI125211, Tocris Bioscience, Histamine H2 Receptor Antagonist products

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