Cat. No. 3040
Chemical Name: (1R*,2S*)-N-(4-Methoxyphenyl)-5-met
Biological ActivityPotent TRPM8 agonist that acts as a cooling agent (EC50 = 193 nM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Beck et al (2007) Prospects for prostate cancer imaging and therapy using high-affinity TRPM8 activators. Cell Calcium 41 285. PMID: 16949669.
Bodding et al (2007) Characterisation of TRPM8 as a pharmacophore receptor. Cell Calcium 42 618. PMID: 17517434.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for WS 12 include:
Morgan et al (2015) Genetic variants affecting human TRPA1 or TRPM8 structure can be classified in vitro as 'well expressed', 'poorly expressed' or 'salvageable'. Biosci Rep 35. PMID: 26330615.
Do you know of a great paper that uses WS 12 from Tocris? If so please let us know.
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Keywords: WS 12, supplier, TRPM8, agonists, cooling, agent, Channels, Transient, Receptor, Potential, WS12, Tocris Bioscience, TRPM Agonist products
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