WS 12

Cat. No. 3040

WS 12 C18H27NO2 [68489-09-8]

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Chemical Name: (1R*,2S*)-N-(4-Methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide

Biological Activity

Potent TRPM8 agonist that acts as a cooling agent (EC50 = 193 nM).

Technical Data

M.Wt:
289.41
Formula:
C18H27NO2
Solubility:
Soluble to 75 mM in ethanol
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
68489-09-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Beck et al (2007) Prospects for prostate cancer imaging and therapy using high-affinity TRPM8 activators. Cell Calcium 41 285. PMID: 16949669.

Bodding et al (2007) Characterisation of TRPM8 as a pharmacophore receptor. Cell Calcium 42 618. PMID: 17517434.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for WS 12 include:

Morgan et al (2015) Genetic variants affecting human TRPA1 or TRPM8 structure can be classified in vitro as 'well expressed', 'poorly expressed' or 'salvageable'. Biosci Rep 35. PMID: 26330615.

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Keywords: WS 12, supplier, TRPM8, agonists, cooling, agent, Channels, Transient, Receptor, Potential, WS12, Tocris Bioscience, TRPM Agonist products

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