Cat. No. 3039
Chemical Name: N-Cycloheptyl-N-(9H-fluoren-2-ylmet
Biological ActivityAcyl-CoA:cholesterol acyltransferase (ACAT) inhibitor (IC50 = 0.18 μM). Exhibits hypocholesterolaemic and antiatherosclerotic activity in vivo.
Licensing InformationSold with the permission of Astellas Pharma Inc.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Miike et al (2008) Effects of an anti-oxidative ACAT inhibitor on apoptosis/necrosis and cholesterol accumulation under oxidative stress in THP-1 cell dervied foam cells. Life Sci. 82 79. PMID: 18037448.
Kamiya et al (2000) Bioavailable acyl-CoA: cholesterol acyltransferase inhibitor with anti-peroxidative activity: synthesis and biological activity of novel indolinyl amide and urea derivatives. Chem.Pharm.Bull. 48 817. PMID: 10866142.
Nagata et al (1995) N-[2-[N'-pentyl-(6,6-dimethyl-2,4-heptadiynyl)amino]ethyl]-(2-methyl-1-naphthylthio)acetamide (FY-087). A new acyl coenzyme A: cholesterol acyltransferase (ACAT) inhibitor of diet-induced atherosclerosis formation in mice. Biochem.Pharmacol. 49 643. PMID: 7887979.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses YM 750 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: YM 750, supplier, Acyl-CoA:cholesterol, acyltransferase, ACAT, inhibitors, inhibits, transferase, YM750, Tocris Bioscience, Acyl-CoA:Cholesterol Acyltransferase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Highly potent and SAM-competitive EZH2 inhibitorGSK 591 dihydrochloride
Potent and selective PRMT5 inhibitorTP 064
Potent and selective PRMT 4 inhibitorBMS 795311
Potent cholesteryl ester transfer protein (CETP) inhibitor
April 22 - 26, 2017
Chicago, IL, USA