TCS 2312

Cat. No. 3038

TCS 2312 C25H24N4O2 [838823-31-7]

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Chemical Name: 4'-[5-[[3-[(Cyclopropylamino)methyl]phenyl]amino]-1H-pyrazol-3-yl]-[1,1'-biphenyl]-2,4-diol

Biological Activity

Potent and selective checkpoint kinase 1 (chk1) inhibitor (Ki = 0.38 nM, EC50 = 60 nM). Enhances the cell killing activity of Gemcitabine (Cat. No. 3259) in breast and prostate cancer cell lines and displays antiproliferative effects in vitro.

Technical Data

M.Wt:
412.48
Formula:
C25H24N4O2
Solubility:
Soluble to 20 mM in DMSO
Purity:
>97 %
Storage:
Store at -20°C
CAS No:
838823-31-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Teng et al (2007) Structure-based design of (5-arylamino-2H-pyrazol-3-yl)-biphenyl-2',4'-diols as novel and potent human CHK1 inhibitors. J.Med.Chem. 50 5253. PMID: 17887663.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for TCS 2312 include:

Davari et al (2014) Checkpoint kinase 2 is required for efficient immunoglobulin diversification. Cell Cycle 13 3659. PMID: 25483076.

Frankenberger et al (2014) Checkpoint kinase 1 negatively regulates somatic hypermutation. Nucleic Acids Res 42 3666. PMID: 24423870.

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Keywords: TCS 2312, supplier, Potent, Chk1, inhibitors, inhibits, Checkpoint, Kinases, Control, TCS2312, Tocris Bioscience, Checkpoint Kinase Inhibitor products

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