Cat. No. 3035
Chemical Name: (1R,5R,6R,7S)-rel-4-Oxo-8-(phenylme
Biological ActivityJAK2/STAT3 signaling pathway inhibitor. Inhibits activation of STAT3, JAK2 and Src. Induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Duan et al (2007) 8-benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid (SD-1008), a novel Janus kinase 2 inhibitor, increases chemotherapy sensitivity in human ovarian cancer cells. Mol.Pharmacol. 72 1137. PMID: 17675586.
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Keywords: SD 1008, supplier, JAK2, STAT3, signaling, pathway, inhibitors, inhibits, activation, Src, SD1008, Tocris Bioscience, STAT Inhibitor products