NSC 109555 ditosylate
Cat. No. 3034
Alternative Name: DDUG
Chemical Name: 4,4'-diacetyldiphenylurea bis(guanylhydrazone) ditosylate
Biological ActivitySelective, reversible, ATP-competitive Chk2 inhibitor (IC50 = 0.2 μM) that displays no effect on a range of other kinases including Chk1 (IC50 > 10 μM). Inhibits histone H1 phosphorylation (IC50 = 0.24 μM) and attenuates mitochondrial ATP synthesis. Exhibits antiproliferative activity in a number of leukemias in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Jobson et al (2007) Identification of a bis-guanylhydrazone [4,4'-diacetyldiphenylurea-bis(guanylhydrazone); NSC 109555] as a novel chemotype for inhibition of Chk2 kinase. Mol.Pharmacol. 72 876. PMID: 17616632.
Byczkowski et al (1982) Potentiation of the antimitochondrial and antiproliferative effects of bis(guanylhydrazones) by phenethylbiguanide. Cancer Res. 42 3592. PMID: 6896674.
Byczkowski et al (1981) Actions of bis(guanylhydrazones) on isolated rat liver mitochondria. Biochem.Pharmacol. 30 2851. PMID: 6895596.
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Citations are publications that use Tocris products. Selected citations for NSC 109555 ditosylate include:
Duong et al (2013) Inhibition of checkpoint kinase 2 (CHK2) enhances sensitivity of pancreatic adenocarcinoma cells to gemcitabine. J Cell Mol Med 17 1261. PMID: 23855452.
Fard et al (2013) The heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway. Cell Cycle 13 408. PMID: 24247150.
Do you know of a great paper that uses NSC 109555 ditosylate from Tocris? If so please let us know.
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Keywords: NSC 109555 ditosylate, supplier, Selective, Chk2, inhibitors, inhibits, Checkpoint, Kinases, Control, NSC109555, ditosylate, Tocris Bioscience, Checkpoint Kinase Inhibitor products
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