Cortistatin-8

Cat. No. 3033

Cortistatin-8 Pro-Cys-Phe-D-Trp-Lys-Thr-Cys-Lys-NH2

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Alternative Name: CST-8

Biological Activity

Synthetic cortistatin analog that lacks the ability to bind somatostatin receptors but retains ghrelin receptor binding. Acts as a ghrelin receptor antagonist; counteracts the response of ghrelin on gastric acid secretion.

Technical Data

M.Wt:
1009.25
Formula:
C47H68N12O9S2
Sequence:
PCFWKTCK

(Modifications: Trp-4 = D-Trp, Disulfide bridge between 2 - 7, Lys-8 = C-terminal amide)

Solubility:
Soluble to 2 mg/ml in 20% acetonitrile
Storage:
Desiccate at -20°C
CAS No:
485803-62-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Prodam et al (2008) Cortistatin-8, a synthetic cortistatin-derived ghrelin receptor ligand, does not modify the endocrine responses to acylated ghrelin or hexarelin in humans. Neuropeptides 42 89. PMID: 18061663.

Luque et al (2006) Cortistatin mimics somatostatin by inducing a dual, dose-dependent stimulatory and inhibitory effect on growth hormone secretion in somatotropes. J.Mol.Endocrinol. 36 547. PMID: 16720722.

Sibilia et al (2006) Evidence for a role of the GHS-R1a receptors in ghrelin inhibition of gastric acid secretion in the rat. J.Neuroendocrinol. 18 122. PMID: 16420281.

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Keywords: Cortistatin-8, supplier, Ghrelin, receptor, antagonists, GHS-R1a, Receptors, Growth, Hormone, Secretagogue, 1a, CST8, Tocris Bioscience, Ghrelin Receptor Antagonist products

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