Rp-8-Br-PET-cGMPS

Cat. No. 3028

Rp-8-Br-PET-cGMPS C18H14BrN5NaO6PS [185246-32-6]

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Chemical Name: 2-Bromo-3,4-dihydro-3-[3,5-O-[(R)-mercaptophosphinylidene]-β-D-ribofuranosyl]-6-phenyl-9H-Imidazo[1,2-a]purin-9-one sodium salt

Biological Activity

Competitive, reversible cGMP-dependent protein kinase (PKG) inhibitor; cGMP analog.

Technical Data

M.Wt:
562.27
Formula:
C18H14BrN5NaO6PS
Solubility:
Soluble to 20 mM in water and to 40 mM in DMSO
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
185246-32-6

Resources

Other Information

  • This product is sold in units of 560μg, equivalent to 1μmol.

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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Valtcheva et al (2008) The commonly used cGMP-dependent protein kinase type I (cGKI) inhibitor Rp-8-Br-PET-cGMPS can activate cGKI in vitro and in intact cells. J.Biol.Chem. 284 556. PMID: 19008225.

Qi et al (2007) Protein kinase G regulates the basal tension and plays a major role in nitrovasodilator-induced relaxation of porcine coronary veins. Br.J.Pharmacol. 152 1060. PMID: 17891157.

Wei et al (1996) Identification of competitive antagonists of the rod photoreceptor cGMP-gated cation channel: beta-phenyl-1,N2-etheno-substituted cGMP analogues as probes of the cGMP-binding site. Biochemistry 35 16815. PMID: 8988020.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Rp-8-Br-PET-cGMPS include:

Berlinguer-Palmini et al (2013) GPR35 activation reduces Ca2+ transients and contributes to the kynurenic acid-dependent reduction of synaptic activity at CA3-CA1 synapses. PLoS One 8 e82180. PMID: 24312407.

Lin et al (2008) Integrin regulation of cytoplasmic calcium in excitatory neurons depends upon glutamate receptors and release from intracellular stores. Cell 37 770. PMID: 18289871.

Do you know of a great paper that uses Rp-8-Br-PET-cGMPS from Tocris? If so please let us know.

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Keywords: Rp-8-Br-PET-cGMPS, supplier, Protein, kinase, G, inhibitors, inhibits, PKG, Kinases, cGMP-dependent, Tocris Bioscience, Protein Kinase G Inhibitor products

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