Cat. No. 3026
Alternative Name: Pranlukast
Chemical Name: N-[4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-
Biological ActivitySelective cysteinyl leukotriene receptor 1 (CysLT1) antagonist (IC50 values are ~ 4 - 7 and 3620 nM for CysLT1 and CysLT2 respectively). Inhibits contraction of airway smooth muscle, microvascular leakage into airways and eosinophil infiltration. Can decrease symptoms of bronchial asthma.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Suzuki et al (2003) Inhibition of human eosinophil activation by a cysteinyl leukotriene receptor antagonist (Pranlukast; ONO-1078). J.Asthma 40 395. PMID: 12870835.
Heise et al (2000) Characterization of the human cysteinyl leukotriene 2 receptor. J.Biol.Chem. 275 30531. PMID: 10851239.
Lynch et al (1999) Characterization of the human leukotriene CysLT1 receptor. Nature 399 789. PMID: 10391245.
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Citations are publications that use Tocris products.
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Keywords: ONO 1078, supplier, Selective, CysLT1, antagonists, Receptors, leukotrienes, eicosanoids, ONO1078, Tocris Bioscience, Leukotriene and Related Receptor Antagonist products
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