ONO 1078

Cat. No. 3026

ONO 1078 C27H23N5O4 [103177-37-3]

Price and Availability

For ONO 1078 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: Pranlukast

Chemical Name: N-[4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4(4-phenylbutoxy)benzamide

Biological Activity

Selective cysteinyl leukotriene receptor 1 (CysLT1) antagonist (IC50 values are ~ 4 - 7 and 3620 nM for CysLT1 and CysLT2 respectively). Inhibits contraction of airway smooth muscle, microvascular leakage into airways and eosinophil infiltration. Can decrease symptoms of bronchial asthma.

Technical Data

M.Wt:
481.5
Formula:
C27H23N5O4
Solubility:
Soluble to 50 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
103177-37-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Suzuki et al (2003) Inhibition of human eosinophil activation by a cysteinyl leukotriene receptor antagonist (Pranlukast; ONO-1078). J.Asthma 40 395. PMID: 12870835.

Heise et al (2000) Characterization of the human cysteinyl leukotriene 2 receptor. J.Biol.Chem. 275 30531. PMID: 10851239.

Lynch et al (1999) Characterization of the human leukotriene CysLT1 receptor. Nature 399 789. PMID: 10391245.

If you know of a relevant reference for ONO 1078 please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses ONO 1078 from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: ONO 1078, supplier, Selective, CysLT1, antagonists, Receptors, leukotrienes, eicosanoids, ONO1078, Tocris Bioscience, Leukotriene and Related Receptor Antagonist products

Quick Order

Find multiple products by catalog number

divider line

Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

Our Cardiovascular Guide highlights over 250 products for cardiovascular research. Request copy or view PDF today.

divider line

Immunology Guide

Immunology Product Listing

Our Immunology listing highlights over 190 products for immunology research. Request copy or view PDF today.

divider line

GPCR Product Listing

GPCR Product Listing

Highlights over 450 products for GPCRs. Request copy or view PDF today.

divider line

Asthma Life Science Poster

Written by Peter J. Barnes

Asthma Life Science Poster

Our Asthma poster highlights key pathways and new therapies used to treat asthma, including those currently in clinical development. Request copy today.

divider line

Cardiovascular Life Science Poster

Written by J.J. Maguire and A.P. Davenport

Cardiovascular Life Science Poster

Our Cardiovascular poster highlights the key G protein-coupled receptors involved in the regulation of vascular reactivity. Request copy or view PDF today.

divider line

New Products in this Area

7α,25-Dihydroxycholesterol

Highly potent GPR183 (EBI2) agonist

AR-C 69931 tetrasodium salt

Highly potent P2Y12 antagonist

FTY 720

Potent S1P receptor agonist; also immunosuppressant

Cinacalcet hydrochloride

Calcium-sensing receptor (CaSR) allosteric agonist; also CYP2D2 inhibitor and Ca2+ channel blocker; orally bioavailable

AMG 837 hemicalcium salt

Potent free fatty acid receptor 1 (FFA1/GPR40) partial agonist

UMB 68

GHB receptor ligand

AZD 1283

High affinity P2Y12 antagonist

Ex 26

Potent and selective S1P1 receptor antagonist

Sign-up for new product e-alerts
divider line

Bio-Techne Events

26th ISN-ESN Biennal Meeting

26th ISN-ESN Biennial Meeting

August 20 - 24, 2017

Paris , France

Booth: 11