AA 2414

Cat. No. 3025

AA 2414 C22H26O4 [112665-43-7]

Price and Availability

For AA 2414 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: Seratrodast

Chemical Name: 7-(3,5,6-Trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoic acid

Biological Activity

Thromboxane A2 (TP) receptor antagonist. Antiasthmatic agent; inhibits platelet aggregation and bronchoconstriction induced by a TXA2 mimetic in guinea pigs.

Technical Data

M.Wt:
354.44
Formula:
C22H26O4
Solubility:
Soluble to 75 mM in 1.1eq. NaOH and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
112665-43-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Cui et al (2007) Leukotrienes and cyclooxygenase products mediate anaphylactic venoconstriction in ovalbumin sensitized rat livers. Eur.J.Pharmacol. 576 99. PMID: 17706964.

Kurokawa et al (1994) Antagonism of the human thromboxane A2 receptor by an anti-asthmatic agent AA-2414. Biol.Pharm.Bull. 17 383. PMID: 8019502.

Ashida et al (1989) A novel anti-asthmatic quinone derivative, AA-2414 with a potent antagonistic activity against a variety of spasmogenic prostanoids. Prostaglandins 38 91. PMID: 2748922.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses AA 2414 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: AA 2414, supplier, Thromboxane, A2, TP, receptors, antagonists, TXA2, Prostanoid, prostaglandins, prostacyclins, eicosanoids, AA2414, Tocris Bioscience, Prostanoid Receptor Antagonist products

Quick Order

Find multiple products by catalog number

divider line

Immunology Guide

Immunology Product Listing

Highlights over 190 products for immunology research. Request copy or view PDF today.

divider line

Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

Highlights over 250 products for cardiovascular research. Request copy or view PDF today.

divider line

Peripheral Sensitization

Written by Grant D. Nicol and Michael R. Vasko

Pain Life Science Poster

A summary of the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. Request copy or view PDF today.

divider line

Regulation of Vascular Reactivity by GPCRs

Written by J.J. Maguire and A.P. Davenport

Cardiovascular Life Science Poster

'Regulation of Vascular Reactivity by G-protein-coupled Receptors' summarizes the key GPCRs regulating vascular reactivity. Request copy today.

divider line

New Therapies and Challenges in Asthma

Written by Peter J. Barnes

Asthma Life Science Poster

'New Therapies, Challenges, and Breakthroughs in Asthma' highlights key pathways and new therapies used to treat asthma, including those currently in clinical development. Request copy today.

divider line

New Products in this Area

SAR 216471 hydrochloride

Potent P2Y12 antagonist; cell permeable

A 971432

Potent and selective S1P5 agonist

GLPG 0974

Potent FFA2 antagonist

Ogerin

Selective positive allosteric modulator at GPR68

BGC 20-1531 hydrochloride

High affinity and selective EP4 antagonist

Montelukast sodium

CysLT1 antagonist

Beraprost sodium

Potent prostacyclin IP receptor agonist

JNJ 63533054

Potent and selective GPR139 agonist

Sign-up for new product e-alerts
divider line

ASCB 2016

Win a $1,000 travel grant

ASCB travel Grant

Bio-Techne is offering 10 travel grants of $1,000 for ASCB 2016.