AA 2414

Cat. No. 3025

AA 2414 C22H26O4 [112665-43-7]

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Alternative Name: Seratrodast

Chemical Name: 7-(3,5,6-Trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoic acid

Biological Activity

Thromboxane A2 (TP) receptor antagonist. Antiasthmatic agent; inhibits platelet aggregation and bronchoconstriction induced by a TXA2 mimetic in guinea pigs.

Technical Data

M.Wt:
354.44
Formula:
C22H26O4
Solubility:
Soluble to 75 mM in 1.1eq. NaOH and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
112665-43-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Cui et al (2007) Leukotrienes and cyclooxygenase products mediate anaphylactic venoconstriction in ovalbumin sensitized rat livers. Eur.J.Pharmacol. 576 99. PMID: 17706964.

Kurokawa et al (1994) Antagonism of the human thromboxane A2 receptor by an anti-asthmatic agent AA-2414. Biol.Pharm.Bull. 17 383. PMID: 8019502.

Ashida et al (1989) A novel anti-asthmatic quinone derivative, AA-2414 with a potent antagonistic activity against a variety of spasmogenic prostanoids. Prostaglandins 38 91. PMID: 2748922.

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View Related Products by Product Action

Keywords: AA 2414, supplier, Thromboxane, A2, TP, receptors, antagonists, TXA2, Prostanoid, prostaglandins, prostacyclins, eicosanoids, AA2414, Tocris Bioscience, Prostanoid Receptor Antagonist products

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