CP 31398 dihydrochloride
Cat. No. 3023
Chemical Name: N'-[2-[2-(4-Methoxyphenyl)ethenyl]-4
Biological Activityp53 stabilizing agent. Stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53. Inhibits growth of small human tumor xenografts in vivo.
Licensing InformationSold for research purposes under agreement from Pfizer Inc.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Demma et al (2004) CP-31398 restores DNA-binding activity to mutant p53 in vitro but does not affect p53 homologs p63 and p73. J.Biol.Chem. 279 45887. PMID: 15308639.
Wischhusen et al (2003) CP-31398, a novel p53-stabilizing agent, induces p53-dependent and p53-independent glioma cell death. Oncogene 22 8233. PMID: 14614447.
Foster et al (1999) Pharmacological rescue of mutant p53 conformation and function. Science 286 2507. PMID: 10617466.
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Citations are publications that use Tocris products. Selected citations for CP 31398 dihydrochloride include:
Grugan et al (2013) A common p53 mutation (R175H) activates c-Met receptor tyrosine kinase to enhance tumor cell invasion. Mol Cell Neurosci 14 853. PMID: 23792586.
Roh et al (2011) p53-Reactivating small molecules induce apoptosis and enhance chemotherapeutic cytotoxicity in head and neck squamous cell carcinoma. Oral Oncol 47 8. PMID: 21109480.
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