Edelfosine

Cat. No. 3022

Edelfosine C27H58NO6P [77286-66-9]

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Alternative Name: ET-18-OCH3

Chemical Name: (7R)-4-Hydroxy-7-methoxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphaheptacosan-1-aminium-4-oxide

Biological Activity

Synthetic lysophospholipid analog that selectively inhibits phosphatidylinositol phospholipase C (IC50= 9.6 μM in fibroblasts and adenocarcinoma cells). Also acts as an agonist at platelet-activating factor (PAF) receptors. Antitumor lipid; selectively induces apoptosis in tumor cells, sparing normal cells.

Technical Data

M.Wt:
523.73
Formula:
C27H58NO6P
Solubility:
Soluble to 5 mM in water with gentle warming and to 100 mM in ethanol
Storage:
Store at -20°C
CAS No:
77286-66-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Shimizu et al (2007) Roles of brain phosphatidylinositol-specific phospholipase C and diacylglycerol lipase in centrally administered histamine-induced adrenomedullary outflow in rats. Eur.J.Pharmacol. 571 138. PMID: 17628524.

Wong et al (2007) Phospholipase C and myosin light chain kinase inhibition define a common step in actin regulation during cytokinesis. BMC Cell Biol. 8 15. PMID: 17509155.

Aoki et al (1995) A radioreceptor binding assay for platelet-activating factor (PAF) using membranes from CHO cells expressing human PAF receptor. J.Immunol.Methods 186 225. PMID: 7594622.

Powis et al (1992) Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues. Cancer Res. 52 2835. PMID: 1316230.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Edelfosine include:

Liu et al (2015) A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis. Sci Signal 8 ra71. PMID: 26198357.

Ozkucur et al (2014) NHE3 phosphorylation via PKCη marks the polarity and orientation of directionally migrating cells. Cell Mol Life Sci 71 4653. PMID: 24788043.

Korb et al (2013) Arc in the nucleus regulates PML-dependent GluA1 transcription and homeostatic plasticity. Nat Neurosci 16 874. PMID: 23749147.

Lee et al (2012) The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature 492 123. PMID: 23143333.

Melchior and Frangos (2012) Gαq/11-mediated intracellular calcium responses to retrograde flow in endothelial cells. Cancer Biol Ther 303 C467. PMID: 22700794.

Do you know of a great paper that uses Edelfosine from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Edelfosine, supplier, Selective, PI-PLC, inhibitors, inhibits, PAF, receptor, Phospholipases, C, Phosphoinositide-Specific, Esterases, Platelet-activating, Factor, Receptors, ET18OCH3, Tocris Bioscience, Phospholipase Inhibitor products

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