Cat. No. 1395
Chemical Name: (R)-3,4-Dicarboxyphenylglycine
Biological ActivityAMPA receptor antagonist with weak activity at NMDA receptors and little activity at kainate receptors. (RS)-3,4-DCPG (Cat. No. 1394) and (S)-3,4-DCPG (Cat. No. 1302) also available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Moldrich et al (2001) Anticonvulsant activity of 3,4-dicarboxyphenylglycines in DBA/2 mice. Neuropharmacology 40 732. PMID: 11311902.
Thomas et al (1997) Dicarboxyphenylglycines antagonize AMPA- but not kainate-induced depolarizations in neonatal rat motoneurones. Eur.J.Pharmacol. 338 111. PMID: 9455991.
If you know of a relevant reference for (R)-3,4-DCPG please let us know.
Citations are publications that use Tocris products. Selected citations for (R)-3,4-DCPG include:
Sun et al (2012) Structure based model for the prediction of phospholipidosis induction potential of small molecules. J Chem Inf Model 52 1798. PMID: 22725677.
Do you know of a great paper that uses (R)-3,4-DCPG from Tocris? If so please let us know.
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Keywords: (R)-3,4-DCPG, supplier, AMPA, antagonists, weak, NMDA, Glutamate, Ionotropic, Non-Selective, iGlur, Receptors, Tocris Bioscience, Non-selective Ionotropic Glutamate Antagonist products