CP 339818 hydrochloride
Cat. No. 1399
Chemical Name: N-[1-(Phenylmethyl)-4(1H)-quinoliny
Biological ActivityPotent, non-peptide KV1.3 channel antagonist that preferentially binds to the C-type inactivated state of the channel (IC50 ~ 200 nM) . Inhibits KV1.4 with an IC50 of ~ 300 nM. Selective over KV1.1, KV1.2, KV1.5, KV1.6, KV3.1-4, and KV4.2.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Jager et al (1998) Regulation of mammalian Shaker-related K+ channels: evidence for non-conducting closed and non-conducting inactivated. J.Physiol. 506 291. PMID: 9490854.
Nguyen et al (1996) Novel nonpeptide agents potently block the C-type inactivated conformation of Kv1.3 and suppress T cell activation. Mol.Pharmacol. 50 1672. PMID: 8967992.
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Citations are publications that use Tocris products. Selected citations for CP 339818 hydrochloride include:
Meredith et al (2015) Kv1 channels and neural processing in vestibular calyx afferents. J Neurosci 9 85. PMID: 26082693.
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Keywords: CP 339818 hydrochloride, supplier, Non-peptide, potent, KV13, channels, blockers, Potassium, KV, voltage-gated, voltage-dependent, K+, CP339818, hydrochloride, Tocris Bioscience, Voltage-gated Potassium (KV) Channel Blocker products