Trichostatin A

Cat. No. 1406

Trichostatin A C17H22N2O3 [58880-19-6]

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Chemical Name: (2E,4E,6R)-7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide

Biological Activity

Selective and potent inhibitor of histone deacetylase (Ki = 3.4 nM). Active in vivo. Potential anti-cancer agent. Induces accelerated dedifferentiation of primordial germ cells (PGCs) into embryonic germ (EG) cells.

Technical Data

M.Wt:
302.37
Formula:
C17H22N2O3
Solubility:
Soluble to 10 mM in ethanol and to 50 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
58880-19-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Durcova-Hills et al (2008) Reprogramming primordial germ cells into pluripotent stem cells. PloS ONE 3 e3531. PMID: 18953407.

Vigushin et al (2001) Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo. Clin.Cancer Res. 7 971. PMID: 11309348.

Wharton et al (2000) Inhibition of mitogenesis in Balb/c-3T3 cells by trichostatin A. J.Biol.Chem. 275 33981. PMID: 10945992.

Yoshida et al (1990) Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J.Biol.Chem. 265 17174. PMID: 2211619.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Trichostatin A include:

Franklin et al (2014) Increased long-term potentiation at medial-perforant path-dentate granule cell synapses induced by selective inhibition of histone deacetylase 3 requires Fragile X mental retardation protein. Neurobiol Learn Mem 114 193. PMID: 24956240.

Biernacka et al (2013) Hyperglycaemia-induced chemoresistance of prostate cancer cells due to IGFBP2. World J Gastroenterol 20 741. PMID: 23959956.

Xia et al (2013) Identification of repurposed small molecule drugs for chordoma therapy. Cancer Biol Ther 14 638. PMID: 23792643.

Kobori et al (2010) Butyrate stimulates IL-32α expression in human intestinal epithelial cell lines. Oncogene 16 2355. PMID: 20480520.

Do you know of a great paper that uses Trichostatin A from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Trichostatin A, supplier, Histone, deacetylase, inhibitors, inhibits, HDAC, Deacetylases, TrichostatinA, stem, cells, epigenetics, Tocris Bioscience, Histone Deacetylase Inhibitor products

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