Cat. No. 1406
Chemical Name: (2E,4E,6R)-7-(4-(Dimethylamino)phen
Biological ActivitySelective and potent inhibitor of histone deacetylase (Ki = 3.4 nM). Active in vivo. Potential anti-cancer agent. Induces accelerated dedifferentiation of primordial germ cells (PGCs) into embryonic germ (EG) cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Durcova-Hills et al (2008) Reprogramming primordial germ cells into pluripotent stem cells. PloS ONE 3 e3531. PMID: 18953407.
Vigushin et al (2001) Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo. Clin.Cancer Res. 7 971. PMID: 11309348.
Wharton et al (2000) Inhibition of mitogenesis in Balb/c-3T3 cells by trichostatin A. J.Biol.Chem. 275 33981. PMID: 10945992.
Yoshida et al (1990) Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J.Biol.Chem. 265 17174. PMID: 2211619.
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Citations are publications that use Tocris products. Selected citations for Trichostatin A include:
Franklin et al (2014) Increased long-term potentiation at medial-perforant path-dentate granule cell synapses induced by selective inhibition of histone deacetylase 3 requires Fragile X mental retardation protein. Neurobiol Learn Mem 114 193. PMID: 24956240.
Biernacka et al (2013) Hyperglycaemia-induced chemoresistance of prostate cancer cells due to IGFBP2. World J Gastroenterol 20 741. PMID: 23959956.
Xia et al (2013) Identification of repurposed small molecule drugs for chordoma therapy. Cancer Biol Ther 14 638. PMID: 23792643.
Kobori et al (2010) Butyrate stimulates IL-32α expression in human intestinal epithelial cell lines. Oncogene 16 2355. PMID: 20480520.
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Keywords: Trichostatin A, supplier, Histone, deacetylase, inhibitors, inhibits, HDAC, Deacetylases, TrichostatinA, stem, cells, epigenetics, Tocris Bioscience, Histone Deacetylase Inhibitor products