Cat. No. 0895
Chemical Name: (S)-(-)-5-Aminosulfonyl-N-[(1-ethyl
Biological ActivityActive enantiomer. Selective D2-like dopamine antagonist (Ki values are ~ 0.015. ~ 0.013, 1, ~ 45 and ~ 77 μM at D2, D3, D4, D1 and D5 receptors respectively). (RS)-(±)-Sulpiride (Cat. No. 0894) also available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Seeman and Van Tol (1994) Dopamine receptor pharmacology. TiPS 15 264. PMID: 7940991.
Seeman and Van Tol (1993) Dopamine D4 receptors bind inactive (+)-aporphines, suggesting neuroleptic role. Sulpiride not stereoselective. Eur.J.Pharmacol. 233 173. PMID: 8097160.
Merck Index 12 9163.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for (S)-(-)-Sulpiride include:
Brzosko et al (2015) Retroactive modulation of spike timing-dependent plasticity by dopamine. Elife 4. PMID: 26516682.
Jensen (2015) Effects of Dopamine D2-Like Receptor Antagonists on Light Responses of Ganglion Cells in Wild-Type and P23H Rat Retinas. PLoS One 10 e0146154. PMID: 26717015.
Ma et al (2015) Agonist and antagonist effects of aripiprazole on D2-like receptors controlling rat brain dopamine synthesis depend on the dopaminergic tone. Int J Neuropsychopharmacol 18. PMID: 25522390.
Marcott et al (2014) Phasic dopamine release drives rapid activation of striatal D2-receptors. Neuron 84 164. PMID: 25242218.
Ishima et al (2012) Neurite outgrowth mediated by the heat shock protein Hsp90α: a novel target for the antipsychotic drug aripiprazole. Transl Psychiatry 2 e170. PMID: 23047241.
Kurita et al (2012) HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity. Nat Neurosci 15 1245. PMID: 22864611.
Chuhma et al (2009) Dopamine neuron glutamate cotransmission: frequency-dependent modulation in the mesoventromedial projection. Neuroscience 164 1068. PMID: 19729052.
Costa et al (2008) Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition. J Neurosci 28 8040. PMID: 18685029.
Wang et al (2006) Dopaminergic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons. Neuron 50 443. PMID: 16675398.
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Keywords: (S)-(-)-Sulpiride, supplier, selective, D2-like, antagonists, Dopamine, Non-Selective, Receptors, D3, D4, dopaminergic, Tocris Bioscience, Non-selective Dopamine Antagonist products
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