Cat. No. 1073
Chemical Name: (RS)-1-Amino-5-phosphonoindan-1-car
Biological ActivityRigidified analog of MPPG (Cat. No. 0853); selective group II metabotropic glutamate receptor antagonist (IC50 = 30 μM) with no significant effect on group I and III mGlu receptors at concentrations up to 1 mM. Increases extracellular glutamate concentrations and possesses unusual inverse agonist-like action.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Xi et al (2002) Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens. J.Pharmacol.Exp.Ther. 300 162. PMID: 11752112.
Krenz et al (2000) Group I, II and III mGluR compounds affect rhythm generation in the gastric circuit of the crustacean stomatogastric ganglion. J.Neurophysiol. 83 1188. PMID: 10712449.
Ma et al (1997) Synthesis and biological activity of cyclic analogues of MPPG and MCPG as metabotropic glutamate receptor antagonists. Bioorg.Med.Chem.Lett. 7 1195.
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Keywords: (RS)-APICA, supplier, Selective, group, II, antagonists, mGlur, Group, Receptors, mGlu2, mGlu3, mGluR2, mGluR3, Glutamate, Metabotropic, Tocris Bioscience, Glutamate (Metabotropic) Group II Receptor Antagonist products
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