AGN 192403 hydrochloride

Cat. No. 1072

AGN 192403 hydrochloride C10H19N.HCl [1021868-90-5]

Price and Availability

For AGN 192403 hydrochloride pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: (±)-2-endo-Amino-3-exo-isopropylbicyclo[2.2.1]heptane hydrochloride

Biological Activity

I1 imidazoline binding site selective ligand with a potency at I1 comparable to moxonidine, but devoid of affinity for adrenoceptors and the I2 binding site. Interestingly, in animal models, this compound causes none of the physiological responses associated with the I1 binding site.

Technical Data

M.Wt:
189.73
Formula:
C10H19N.HCl
Solubility:
Soluble to 100 mM in water
Storage:
Store at RT
CAS No:
1021868-90-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

Mukaddam-Daher et al (2006) Receptors involved in moxonidine-stimulated strial natriuretic peptide released from isolated normotensive rat hearts. Eur.J.Pharmacol. 541 73. PMID: 16774751.

Raasch et al (2002) Agmatine, an endogenous ligand at imidazoline binding sites, does not antagonize the clonidine-mediated blood pressure reaction. Br.J.Pharmacol. 135 663. PMID: 11834614.

Munk et al (1996) Synthesis and pharmacologic evaluation of 2-endo-amino-3-exo-isopropylbicyclo[2.2.1]heptane: a potent imidazoline1 receptor specific agent. J.Med.Chem. 39 1193. PMID: 8632424.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for AGN 192403 hydrochloride include:

Sánchez-Blázquez et al (2000) Activation of I(2)-imidazoline receptors enhances supraspinal morphine analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br J Pharmacol 130 146. PMID: 10781010.

Do you know of a great paper that uses AGN 192403 hydrochloride from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: AGN 192403 hydrochloride, supplier, I1, selective, ligands, Imidazoline, Receptors, AGN192403, hydrochloride, Tocris Bioscience, I1 Receptor products

Quick Order

Find multiple products by catalog number

divider line

New Product Guide

New Product Guide (Spring/Summer 2016)

Our New Product guide highlights over 110 new products added in the first half of 2016. View PDF today.

divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.