Cat. No. 1405
Chemical Name: (1R,6S)-3-Hydroxy-4-methyl-7-oxabic
Biological ActivitySelective inhibitor of Bruton's tyrosine kinase (BTK). Inhibits the interaction between PKCbII and BTK (IC50 ~ 30 mM) and the catalytic activity of BTK but does not affect the activity of PKC. Has little effect on the activities of Lyn, Syk, PKA, casein kinase I, ERK1, ERK2 and p38 kinases.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Kawakami et al (1999) Terreic acid, a quinone epoxide inhibitor of Bruton's tyrosine kinase. Proc.Natl.Acad.Sci.U.S.A. 96 2227. PMID: 10051623.
Subramanian et al (1982) In vivo and in vitro studies on the binding nature of terreic acid with macromolecules such as protein and nucleic acids. Toxicol.Lett. 10 249. PMID: 7080093.
Yamamoto et al (1980) Studies on terreic acid. Jpn.J.Antibiot. 33 320. PMID: 7190624.
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Keywords: Terreic acid, supplier, Selective, inhibitors, inhibits, BTK, Brutons, Tyrosine, Kinases, Tocris Bioscience, Bruton's Tyrosine Kinase Inhibitor products
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