Cat. No. 1384
Chemical Name: 4-[[[(3-Chlorophenyl)amino]carbonyl
Biological ActivitySelective muscarinic M1 receptor agonist. Selectivity for M1 over other muscarinic receptor types appears to arise from a high efficacy at M1 receptors.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Davies et al (2001) Inhibition of field stimulation-induced contractions of rabbit vas deferens by muscarinic receptor agonists: selectivity of McN-A-343 for M1 receptors. J.Pharm.Pharmacol. 53 487. PMID: 11341365.
Eglen et al (1996) Muscarinic receptor subtypes and smooth muscle function. Pharmacol.Rev. 48 531. PMID: 8981565.
Micheletti and Schiavone (1990) Functional determination of McN-A-343 affinity for M1 muscarinic receptors. J.Pharmacol.Exp.Ther. 253 310. PMID: 1691785.
If you know of a relevant reference for McN-A 343 please let us know.
Citations are publications that use Tocris products. Selected citations for McN-A 343 include:
Park et al (2013) Inactivation of JAK2/STAT3 signaling axis and downregulation of M1 mAChR cause cognitive impairment in klotho mutant mice, a genetic model of aging. Korean J Anesthesiol 38 1426. PMID: 23389690.
Do you know of a great paper that uses McN-A 343 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: McN-A 343, supplier, Selective, M1, muscarinic, agonists, Receptors, Acetylcholine, ACh, McNA343, Tocris Bioscience, M1 Receptor Agonist products
Find multiple products by catalog number
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.