McN-A 343

Cat. No. 1384

McN-A 343 C14H18Cl2N2O2 [55-45-8]

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Chemical Name: 4-[[[(3-Chlorophenyl)amino]carbonyl]oxy]-N,N,N-trimethyl-2-butyn-1-aminium chloride

Biological Activity

Selective muscarinic M1 receptor agonist. Selectivity for M1 over other muscarinic receptor types appears to arise from a high efficacy at M1 receptors.

Technical Data

M.Wt:
317.21
Formula:
C14H18Cl2N2O2
Solubility:
Soluble to 100 mM in water
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
55-45-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Davies et al (2001) Inhibition of field stimulation-induced contractions of rabbit vas deferens by muscarinic receptor agonists: selectivity of McN-A-343 for M1 receptors. J.Pharm.Pharmacol. 53 487. PMID: 11341365.

Eglen et al (1996) Muscarinic receptor subtypes and smooth muscle function. Pharmacol.Rev. 48 531. PMID: 8981565.

Micheletti and Schiavone (1990) Functional determination of McN-A-343 affinity for M1 muscarinic receptors. J.Pharmacol.Exp.Ther. 253 310. PMID: 1691785.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for McN-A 343 include:

Park et al (2013) Inactivation of JAK2/STAT3 signaling axis and downregulation of M1 mAChR cause cognitive impairment in klotho mutant mice, a genetic model of aging. Korean J Anesthesiol 38 1426. PMID: 23389690.

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Keywords: McN-A 343, supplier, Selective, M1, muscarinic, agonists, Receptors, Acetylcholine, ACh, McNA343, Tocris Bioscience, M1 Receptor Agonist products

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