Cat. No. 0631
Chemical Name: 8-[(2,3-Dihydro-1,4-benzodioxin-2-y
Biological Activity5-HT1A antagonist. More active and selective than spiperone. Also a very potent α2C adrenergic receptor antagonist.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
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Bylund et al (1992) Pharmacological characteristics of α2-adrenergic receptors: comparison of pharmacologically defined subtypes with subtypes identified by molecular cloning. Mol.Pharmacol. 42 1. PMID: 1353247.
Schoeffter and Hoyer (1988) Centrally acting hypotensive agents with affinity for 5-HT1A binding sites inhibit forskolin-stimulated adenylate cyclase activity in calf hippocampus. Br.J.Pharmacol. 95 975. PMID: 3207999.
Nelson and Taylor (1986) Spiroxatrine: a selective serotonin 1A receptor antagonist. Eur.J.Pharmacol. 124 207. PMID: 3720840.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for Spiroxatrine include:
Moura et al (2006) Alpha2-adrenoceptor subtypes involved in the regulation of catecholamine release from the adrenal medulla of mice. Br J Pharmacol 149 1049. PMID: 17075569.
Do you know of a great paper that uses Spiroxatrine from Tocris? If so please let us know.
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