Spiroxatrine

Cat. No. 0631

Spiroxatrine
 C22H25N3O3 [1054-88-2]

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Chemical Name: 8-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one

Biological Activity

5-HT1A antagonist. More active and selective than spiperone. Also a very potent α2C adrenergic receptor antagonist.

Technical Data

M.Wt:
379.46
Formula:
C22H25N3O3
Solubility:
Soluble to 10 mM in DMSO
Storage:
Store at RT
CAS No:
1054-88-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service
Safety Data Sheet: View Safety Data Sheet

Bylund et al (1992) Pharmacological characteristics of α2-adrenergic receptors: comparison of pharmacologically defined subtypes with subtypes identified by molecular cloning. Mol.Pharmacol. 42 1. PMID: 1353247.

Schoeffter and Hoyer (1988) Centrally acting hypotensive agents with affinity for 5-HT1A binding sites inhibit forskolin-stimulated adenylate cyclase activity in calf hippocampus. Br.J.Pharmacol. 95 975. PMID: 3207999.

Nelson and Taylor (1986) Spiroxatrine: a selective serotonin 1A receptor antagonist. Eur.J.Pharmacol. 124 207. PMID: 3720840.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Spiroxatrine include:

Moura et al (2006) Alpha2-adrenoceptor subtypes involved in the regulation of catecholamine release from the adrenal medulla of mice. Br J Pharmacol 149 1049. PMID: 17075569.

Do you know of a great paper that uses Spiroxatrine from Tocris? If so please let us know.

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