Spermine tetrahydrochloride

Cat. No. 0958

Spermine tetrahydrochloride C10H26N4.4HCl [306-67-2]

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Chemical Name: N,N'-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride

Biological Activity

Polyamine which produces a variety of modulatory effects on the NMDA receptor channel, acting through a specific site on the complex which can cause both agonist and antagonist effects.

Technical Data

M.Wt:
348.19
Formula:
C10H26N4.4HCl
Solubility:
Soluble to 100 mM in water
Storage:
Desiccate at +4°C
CAS No:
306-67-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Doyle and Shaw (1998) Investigation of the actions and antagonist activity of some polyamine analogues in vivo. Br.J.Pharmacol. 124 386. PMID: 9641557.

Johnson (1996) Modulation of channel function by polyamines. TiPS 17 22. PMID: 8789355.

Benveniste and Mayer (1993) Multiple effects of spermine on N-methyl-D-aspartic acid receptor responses of rat cultured hippocampal neurones. J.Physiol. 464 131. PMID: 8229795.

Munir et al (1993) Polyamines modulate the neurotoxic effects of NMDA in vivo. Brain Res. 616 163. PMID: 8358608.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Spermine tetrahydrochloride include:

McGee et al (2015) Auxiliary Subunit GSG1L Acts to Suppress Calcium-Permeable AMPA Receptor Function. J Neurosci 35 16171. PMID: 26658868.

Quintana et al (2015) Acid-sensing ion channel 1a drives AMPA receptor plasticity following ischaemia and acidosis in hippocampal CA1 neurons. Proc Natl Acad Sci U S A 593 4373. PMID: 26174503.

Soto et al (2014) Molecular mechanisms contributing to TARP regulation of channel conductance and polyamine block of calcium-permeable AMPA receptors. J Neurosci 34 11673. PMID: 25164663.

Biase et al (2011) NMDA receptor signaling in oligodendrocyte progenitors is not required for oligodendrogenesis and myelination. J Physiol 31 12650. PMID: 21880926.

Zonouzi et al (2011) Bidirectional plasticity of calcium-permeable AMPA receptors in oligodendrocyte lineage cells. Nat Neurosci 14 1430. PMID: 21983683.

Campioni et al (2009) Stress-induced changes in nucleus accumbens glutamate synaptic plasticity. J Neurosci 101 3192. PMID: 19357347.

Soto et al (2009) Selective regulation of long-form calcium-permeable AMPA receptors by an atypical TARP, gamma-5. Nat Neurosci 12 277. PMID: 19234459.

Do you know of a great paper that uses Spermine tetrahydrochloride from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Spermine tetrahydrochloride, supplier, modulators, polyamine, site, Glutamate, NMDA, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, Tocris Bioscience, NMDA Receptor products

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