Spermidine trihydrochloride

Cat. No. 0959

Spermidine trihydrochloride C7H19N3.3HCl [334-50-9]

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Chemical Name: N-(3-Aminopropyl)-1,4-butanediamine trihydrochloride

Biological Activity

Binds to the polyamine modulatory site of the NMDA receptor and has been described as an agonist based on its ability to enhance the binding of [3H]-MK801.

Technical Data

M.Wt:
254.63
Formula:
C7H19N3.3HCl
Solubility:
Soluble to 100 mM in water
Storage:
Desiccate at +4°C
CAS No:
334-50-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Kishi et al (1998) Spermidine, a polyamine site agonist, attenuates working memory deficits caused by blockade of hippocampal muscarinic receptors and mGluRs in rats. Brain Res. 793 311. PMID: 9630697.

Munir et al (1993) Polyamines modulate the neurotoxic effects of NMDA in vivo. Brain Res. 616 163. PMID: 8358608.

Williams et al (1989) Effects of polyamines on the binding of [3H]-MK801 to the N-methyl-D-aspartate receptor: pharmacological evidence for the existence of a polyamine recognition site. Mol.Pharmacol. 36 375. PMID: 2554112.

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Keywords: Spermidine trihydrochloride, supplier, Agonist, polyamine, site, Glutamate, NMDA, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, Tocris Bioscience, NMDA Receptor Agonist products

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