Sotalol hydrochloride

Cat. No. 0952

Sotalol hydrochloride C12H20N2O3S.HCl [959-24-0]

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Chemical Name: N-[4-[1-Hydroxy-2-[(1-methylethyl)amino]ethyl]phenyl]methanesulfonamide hydrochloride

Biological Activity

A relatively potent pure β adrenergic antagonist, unique in possessing additional class III antiarrhythmic activity. Also available as part of the Mixed Adrenergic Tocriset™.

Technical Data

M.Wt:
308.82
Formula:
C12H20N2O3S.HCl
Solubility:
Soluble to 50 mM in water
Purity:
>99 %
Storage:
Store at RT
CAS No:
959-24-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Fiset et al (1997) Block of Iks by the diuretic agent indapamide modulates cardiac electrophysiological effects of the class III antiarrhythmic drug dl-sotalol. J.Pharmacol.Exp.Ther. 283 148. PMID: 9336319.

Claudel and Touboul (1995) Sotalol: from 'just another beta blocker' to 'the prototype class III antidysrhythmic compound'. Pacing Clin.Electrophysiol. 18 451. PMID: 7770366.

Uloth et al (1966) Sulfonanilides. I. Monoalkyl- and arylsulfonamidophenethanolamines. J.Med.Chem. 9 88. PMID: 6006227.

Merck Index 12 8876.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Sotalol hydrochloride include:

Kaya et al (2009) Coupling of β2-adrenoceptors to XLαs and Gαs: a new insight into ligand-induced G protein activation. J Neurosci 329 350. PMID: 19144685.

Woo et al (2007) Neuregulin-1 enhances depolarization-induced GABA release. Neuron 54 599. PMID: 17521572.

Do you know of a great paper that uses Sotalol hydrochloride from Tocris? If so please let us know.

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Keywords: Sotalol hydrochloride, supplier, β-adrenoceptor, beta-adrenoceptors, b-adrenergic, β-adrenergic, beta-adrenergic, b-adrenoceptors, antagonists, Receptors, Non-Selective, Tocris Bioscience, Non-selective Adrenergic β Receptor Antagonist products

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