SNC 80

Cat. No. 0764

SNC 80 C28H39N3O2 [156727-74-1]

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Chemical Name: (+)-4-[(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide

Biological Activity

A highly selective and potent non-peptide δ-opioid agonist, 2000-fold selective over μ-opioid receptors.

Technical Data

M.Wt:
449.64
Formula:
C28H39N3O2
Solubility:
Soluble to 100 mM in 1eq. HCl with gentle warming and to 20 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
156727-74-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Knapp et al (1996) Structure-activity relationships for SNC80 and related compounds at cloned human delta and mu opioid receptors. J.Pharmacol.Exp.Ther. 277 1284. PMID: 8667189.

Bilsky et al (1995) SNC 80, a selective, nonpeptidic and systemically active opioid δ agonist. J.Pharmacol.Exp.Ther. 273 359. PMID: 7714789.

Calderon et al (1994) Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4-[(αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (SNC80): a highly selective nonpeptide σ opioid receptor agonist. J.Med.Chem. 37 2125. PMID: 8035418.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for SNC 80 include:

Erbs et al (2015) A μ-δ opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networks. J Neurosci 220 677. PMID: 24623156.

Levoye et al (2015) A Broad G Protein-Coupled Receptor Internalization Assay that Combines SNAP-Tag Labeling, Diffusion-Enhanced Resonance Energy Transfer, and a Highly Emissive Terbium Cryptate. Brain Struct Funct 6 167. PMID: 26617570.

Ong et al (2015) Prolonged morphine treatment alters δ opioid receptor post-internalization trafficking. Front Endocrinol (Lausanne) 172 615. PMID: 24819092.

Schuster et al (2015) Ligand requirements for involvement of PKCη in synergistic analgesic interactions between spinal μ and δ opioid receptors. Transl Oncol 172 642. PMID: 24827408.

Pradhan et al (2014) δ-Opioid receptor agonists inhibit migraine-related hyperalgesia, aversive state and cortical spreading depression in mice. Br J Pharmacol 171 2375. PMID: 24467301.

Burbassi et al (2010) Alterations of CXCR4 function in μ-opioid receptor-deficient glia. Eur J Neurosci 32 1278. PMID: 20880358.

Markkanen and Petäjä-Repo (2008) N-glycan-mediated quality control in the endoplasmic reticulum is required for the expression of correctly folded delta-opioid receptors at the cell surface. J Biol Chem 283 29086. PMID: 18703511.

Scherrer et al (2006) Knockin mice expressing fluorescent delta-opioid receptors uncover G protein-coupled receptor dynamics in vivo. Proc Natl Acad Sci U S A 103 9691. PMID: 16766653.

Gomes et al (2000) Heterodimerization of μ and δ opioid receptors: A role in opiate synergy. Br J Pharmacol 20 RC110. PMID: 11069979.

Do you know of a great paper that uses SNC 80 from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: SNC 80, supplier, selective, non-peptide, δ-opioid, delta-opioid, agonists, DOP, Receptors, OP1, SNC80, Tocris Bioscience, δ Opioid Receptor Agonist products

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