Cat. No. 0598
Chemical Name: (S)-Nitroso-N-acetylpenicillamine
Biological ActivityA stable analog of endogenous S-nitroso compounds. A source of NO in vivo which unlike organic O-nitrates does not induce tolerance. Decomposes slowly in solution with a t½ of 37h.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Ferrero et al (1999) Comparative effects of several nitric oxide donors on intracellular cyclic GMP levels in bovine chromaffin cells: correlation with nitric oxide production. Br.J.Pharmacol. 127 779. PMID: 10401570.
Ekblad and Sundler (1997) Motor responses in rat ileum evoked by nitric oxide donors vs. field stimulation: modulation by pituitary adenylate cyclase-activating peptide, forskolin and guanylate cyclase inhibitors. J.Pharmacol.Exp.Ther. 283 23. PMID: 9336304.
Cross et al (1994) Neurotoxicity in conscious rats following intraventricular SNAP, a nitric oxide donor. Neuropharmacology 33 915. PMID: 7969812.
Bauer and Fung (1991) Differential thermodynamic effects and tolerance properties of nitroglycerin and S-nitrosothiol in experimental heart failure. J.Pharmacol.Exp.Ther. 256 249. PMID: 1899118.
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Citations are publications that use Tocris products. Selected citations for SNAP include:
Cheng et al (2011) Biphasic effect of nitric oxide on the cardiac voltage-dependent anion channel. FEBS Lett 585 328. PMID: 21156174.
Rodríguez-Muñoz et al (2011) NO-released zinc supports the simultaneous binding of Raf-1 and PKCγ cysteine-rich domains to HINT1 protein at the mu-opioid receptor. Antioxid Redox Signal 14 2413. PMID: 21235400.
Sunters et al (2010) Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-independent activation of beta-catenin signaling. J Biol Chem 285 8743. PMID: 20042609.
Sachs et al (2004) Peripheral analgesic blockade of hypernociception: activation of arginine/NO/cGMP/protein kinase G/ATP-sensitive K+ channel pathway. Proc Natl Acad Sci U S A 101 3680. PMID: 14990791.
Nistri et al (2002) High-Yield Method for Isolation and Culture of Endothelial Cells from Rat Coronary Blood Vessels Suitable for Analysis of Intracellular Calcium and Nitric Oxide Biosynthetic Pathways. Evid Based Complement Alternat Med 4 32. PMID: 12734571.
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Keywords: SNAP, supplier, stable, endogenous, S-nitroso, ROS, Donors, NO, Precursors, Nitric, Oxide, Signaling, Signalling, Tocris Bioscience, NO Donors / Precursor products