Cat. No. 0379
Alternative Name: CGP 35024
Chemical Name: 3-Aminopropyl(methyl)phosphinic acid
Biological ActivityVery potent GABAB agonist, at least ten times more active than baclofen (Cat. No. 0417). Also GABAA-ρ antagonist.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Bon and Galvan (1996) Electrophysiological characterization of GABAB agonists and antagonists in dorso-lateral septal neurones in vitro. Br.J.Pharmacol. 118 961. PMID: 8799569.
Johnston (1996) GABAC receptors: relatively simple transmitter-gated ion channels? TiPS 17 319. PMID: 8885697.
Froestl et al (1995) Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists. J.Med.Chem. 38 3297. PMID: 7650684.
Seabrook et al (1990) Electrophysiological characterization of potent agonists and antagonists on pre- and postsynaptic GABAB receptors on neurones in brain slices. Br.J.Pharmacol. 101 949. PMID: 1964824.
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Citations are publications that use Tocris products. Selected citations for SKF 97541 include:
Chen et al (2008) Differential regulation of morphine antinociceptive effects by endogenous enkephalinergic system in the forebrain of mice. Mol Pain 4 41. PMID: 18826595.
Root et al (2008) A presynaptic gain control mechanism fine-tunes olfactory behavior. Neuron 59 311. PMID: 18667158.
Piqueras and Martínez (2004) Peripheral GABAB agonists stimulate gastric acid secretion in mice. Br J Pharmacol 142 1038. PMID: 15210585.
Do you know of a great paper that uses SKF 97541 from Tocris? If so please let us know.
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Keywords: SKF 97541, supplier, potent, GABAB, agonists, GABAC, antagonists, Receptors, SKF97541, CGP35024, Tocris Bioscience, GABAB Receptor Agonist products
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