SKF 91488 dihydrochloride
Cat. No. 0512
Chemical Name: 4-(N,N-Dimethylamino)butylisothiour
Biological ActivityHomolog of dimaprit (Cat. No. 0506); strong inhibitor of histamine N-methyltransferase. Exhibits no histamine agonist activity.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
on-line. Please contact Customer Service
References are publications that support the products' biological activity.
Aiello et al (1997) Effects of two histamine-N-methyltransferase inhibitors, SKF 91488 and BW 301U, in rodent antinociception. Naunyn Schmiedebergs Arch.Pharmacol. 355 354. PMID: 9089666.
Ohuri et al (1992) Histamine N-methyl transferase controls the contractile response of guinea pig trachea to histamine. J.Pharmacol.Exp.Ther. 261 1268. PMID: 1534842.
Beaven and Shaff (1979) New inhibitors of histamine N-methyl-transferase. Biochem.Pharmacol. 28 183. PMID: 34400.
Beaven and Shaff (1979) Inhibition of histamine methylation in vivo by the dimaprit analog SKF compound 91488. Agents Actions 9 455. PMID: 161853.
If you know of a relevant reference for SKF 91488 dihydrochloride please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses SKF 91488 dihydrochloride from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: SKF 91488 dihydrochloride, supplier, Histamine, N-methyltransferase, inhibitors, inhibits, transferases, Histaminergic-related, Compounds, Receptors, SKF91488, dihydrochloride, Tocris Bioscience, Other Transferase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Potent and selective SAM-competitive EZH2 inhibitorBRD 4770
G9a inhibitor and S-adenosyl methionine mimetic; cell permeableLys-CoA
Selective p300 inhibitorUNC 2399
Biotinylated UNC 1999 (Cat.No. 4904)PF 06726304 acetate
Highly potent and SAM-competitive EZH2 inhibitorGSK 591 dihydrochloride
Potent and selective PRMT5 inhibitorTP 064
Potent and selective PRMT 4 inhibitor
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.