SKF 38393 hydrobromide

Cat. No. 0922

SKF 38393 hydrobromide C16H17NO2.HBr [20012-10-6]

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Chemical Name: (±)-1-Phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diol hydrobromide

Biological Activity

Prototypical D1-like dopamine receptor selective partial agonist (Ki values are 1, ~ 0.5, ~ 150, ~ 5000 and ~ 1000 nM for D1, D5, D2, D3 and D4 receptors respectively).

Technical Data

M.Wt:
336.23
Formula:
C16H17NO2.HBr
Solubility:
Soluble to 25 mM in water with gentle warming and to 25 mM in ethanol with gentle warming
Purity:
>99 %
Storage:
Desiccate at -20°C
CAS No:
20012-10-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Geter-Douglass et al (1997) Characterization of unconditioned behavioral effects of dopamine D3/D2 receptor agonists. J.Pharmacol.Exp.Ther. 283 7. PMID: 9336302.

Habuchi et al (1997) Dopamine stimulation of cardiac β-adrenoceptors: the involvement of sympathetic amine transporters and the effect of SKF38393. Br.J.Pharmacol. 122 1669. PMID: 9422813.

Seeman and Van Tol (1994) Dopamine receptor pharmacology. TiPS 15 264. PMID: 7940991.

Sibley et al (1982) Interactions of novel dopaminergic ligands with D1 and D2 dopamine receptors. Life Sci. 31 637. PMID: 6127585.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for SKF 38393 hydrobromide include:

Tozzi et al (2015) Endogenous 17β-estradiol is required for activity-dependent long-term potentiation in the striatum: interaction with the dopaminergic system. Front Cell Neurosci 9 192. PMID: 26074768.

Moreno et al (2014) Cocaine disrupts histamine H3 receptor modulation of dopamine D1 receptor signaling: σ1-D1-H3 receptor complexes as key targets for reducing cocaine's effects. J Neurosci 34 3545. PMID: 24599455.

Jia et al (2013) Age-dependent regulation of synaptic connections by dopamine D2 receptors. Nat Neurosci 16 1627. PMID: 24121738.

Murugan et al (2013) Diminished FoxP2 levels affect dopaminergic modulation of corticostriatal signaling important to song variability. Neuron 80 1464. PMID: 24268418.

Burgess et al (2010) Dopaminergic regulation of sleep and cataplexy in a murine model of narcolepsy. Sleep 33 1295. PMID: 21061851.

Do you know of a great paper that uses SKF 38393 hydrobromide from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: SKF 38393 hydrobromide, supplier, Selective, D1-like, agonists, Dopamine, D1, Receptors, D5, dopaminergic, SKF38393, hydrobromide, Tocris Bioscience, D1 and D5 Receptor Agonist products

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