SIN-1 chloride

Cat. No. 0756

SIN-1 chloride C6H11ClN4O2 [16142-27-1]

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Alternative Name: 3-Morpholinylsydnoneimine chloride

Chemical Name: Amino-3-morpholinyl-1,2,3-oxadiazolium chloride

Biological Activity

This compound (the active product of the prodrug SIN-10, molsidomine) acts as a vasodilator and inhibitor of platelet aggregation; longer acting than nitroprusside or nitroglycerin. Decreases myocardial necrosis and reperfusion-induced endothelial dysfunction in models of myocardial ischemia-reperfusion.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
>98 %
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Siegfried et al (1992) Cardioprotection and attenuation of endothelial dysfunction by organic nitric oxide donors in myocardial ichemia-reperfusion. J.Pharmacol.Exp.Ther. 260 668. PMID: 1738117.

Maurice and Heslam (1990) Molecular basis of the synergistic inhibition of platelet function by nitrovasodilators and activators of adenylate cyclase: inhibition of cyclic AMP breakdown by cyclic GMP. Mol.Pharmacol. 37 671. PMID: 2160060.

Nishikawa et al (1982) Inhibition of platelet aggregation and stimulation of guanylate cyclase by an anti-anginal agent molsidomine and its metabolite. J.Pharmacol.Exp.Ther. 220 183. PMID: 6118429.

Tanayama et al (1974) Biotransformation of molsidomine (SIN-10), a new anti-anginal agent in rats. Xenobiotica 4 175.

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Keywords: SIN-1 chloride, supplier, Water-soluble, NO, donor, Guanylyl, cyclases, activators, ROS, Donors, sGC, Precursors, Nitric, Oxide, Signaling, Signalling, vasodilator, Tocris Bioscience, NO Donors / Precursor products

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