SCH 202676 hydrobromide

Cat. No. 1400

SCH 202676 hydrobromide C15H13N3S.HBr [265980-25-4]

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Chemical Name: N-(2,3-Diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)methanamine hydrobromide

Biological Activity

Sulphydryl-reactive compound that inhibits agonist and antagonist binding to G-protein-coupled receptors. Inhibits a variety of GPCRs including adenosine, opioid, muscarinic, adrenergic and dopaminergic receptors (IC50 values are 0.1-1.8 μM).

Technical Data

Soluble to 25 mM in DMSO with gentle warming
>99 %
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Lewandowicz et al (2006) The 'allosteric modulator' SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms. Br.J.Pharmacol. 147 422. PMID: 16402041.

Gao et al (2004) Effects of the allosteric modulator SCH-202676 on adenosine and P2Y receptors. Life Sci. 74 3173. PMID: 15081581.

Fawzi et al (2001) SCH-202676: an allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors. Mol.Pharmacol. 59 30. PMID: 11125021.

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Citations are publications that use Tocris products.

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Keywords: SCH 202676 hydrobromide, supplier, inhibitors, inhibits, ligand, binding, G-protein-coupled, receptors, SCH202676, hydrobromide, Tocris Bioscience, G Protein (Heterotrimeric) Inhibitor products

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