NU 1025

Cat. No. 1401

NU 1025 C9H8N2O2 [90417-38-2]

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Chemical Name: 8-Hydroxy-2-methyl-4(3H)-quinazolinone

Biological Activity

Novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP). Ki and IC50 values are 48 and 400 nM respectively.

Technical Data

M.Wt:
176.17
Formula:
C9H8N2O2
Solubility:
Soluble to 100 mM in 1eq. NaOH and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
90417-38-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Delaney et al (2000) Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines. Clin.Cancer.Res. 6 2860. PMID: 10914735.

Bowman et al (1998) Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064. Br.J.Cancer. 78 1269. PMID: 9823965.

Griffin et al (1998) Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP). J.Med.Chem. 41 5247. PMID: 9857092.

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Keywords: NU 1025, supplier, Potent, PARP, inhibitors, inhibits, PolyADP-ribose, Polymerases, NU1025, Tocris Bioscience, Poly(ADP-Ribose) Polymerase Inhibitor products

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