Cat. No. 1401
Chemical Name: 8-Hydroxy-2-methyl-4(3H)-quinazolin
Biological ActivityNovel, potent inhibitor of poly(ADP-ribose) polymerase (PARP). Ki and IC50 values are 48 and 400 nM respectively.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Delaney et al (2000) Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines. Clin.Cancer.Res. 6 2860. PMID: 10914735.
Bowman et al (1998) Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064. Br.J.Cancer. 78 1269. PMID: 9823965.
Griffin et al (1998) Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP). J.Med.Chem. 41 5247. PMID: 9857092.
If you know of a relevant reference for NU 1025 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses NU 1025 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: NU 1025, supplier, Potent, PARP, inhibitors, inhibits, PolyADP-ribose, Polymerases, NU1025, Tocris Bioscience, Poly(ADP-Ribose) Polymerase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Potent PARP inhibitor; orally bioavailableEntecavir
Potent and selective hepatitis B virus inhibitor
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.