Cat. No. 0226
Biological ActivityGlycine agonist at the NMDA receptor. L-Serine (Cat. No. 0227) also available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Mothet et al (2000) D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor. Proc.Natl.Acad.Sci.USA 97 4926. PMID: 10781100.
Schell et al (1997) D-Serine as a neuromodulator: regional and developmental localizations in rat brain glia resemble NMDA receptors. J. Neurosci. 17 1604. PMID: 9030620.
Lodge (1989) Non-competitive NMDA antagonists. The NMDA Receptor (2nd edition). Eds. G.L.Collingr 37.
If you know of a relevant reference for D-Serine please let us know.
Citations are publications that use Tocris products. Selected citations for D-Serine include:
Laprell et al (2015) Optical control of NMDA receptors with a diffusible photoswitch. Proc Natl Acad Sci U S A 6 8076. PMID: 26311290.
Shin et al (2015) Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens. J Neurosci 112 8124. PMID: 26080439.
Lee et al (2012) Lovastatin modulates glycogen synthase kinase-3β pathway and inhibits mossy fiber sprouting after pilocarpine-induced status epilepticus. J Biol Chem 7 e38789. PMID: 22761705.
Potier et al (2010) Contribution of the d-Serine-Dependent Pathway to the Cellular Mechanisms Underlying Cognitive Aging. Front Aging Neurosci 2 1. PMID: 20552041.
Inoue et al (2008) NMDA- and β-amyloid1-42-induced neurotoxicity is attenuated in serine racemase knock-out mice. PLoS One 28 14486. PMID: 19118183.
Morante-Oria et al (2003) Subpallial origin of a population of projecting pioneer neurons during corticogenesis. Proc Natl Acad Sci U S A 100 12468. PMID: 14523241.
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Keywords: D-Serine, supplier, Potentiator, glycine, site, Glutamate, NMDA, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, Tocris Bioscience, NMDA Receptor products