Saclofen

Cat. No. 0246

Saclofen C9H12ClNO3S [125464-42-8]

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Chemical Name: (RS)-3-Amino-2-(4-chlorophenyl)propylsulfonic acid

Biological Activity

Selective antagonist at GABAB receptors.

Technical Data

M.Wt:
249.72
Formula:
C9H12ClNO3S
Solubility:
Soluble to 10 mM in water
Purity:
>99 %
Storage:
Store at RT
CAS No:
125464-42-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Jane et al (1990) Use of the neonatal rat spinal cord in studies of the GABAB receptor. GABAB receptors in Mammalian Function. 42b.

Bowery (1989) GABAB receptors and their significance in mammalian pharmacology. TiPS 10 401. PMID: 2559518.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Saclofen include:

Harte-Hargrove et al (2015) Opioid receptor-dependent sex differences in synaptic plasticity in the hippocampal mossy fiber pathway of the adult rat. Br J Pharmacol 35 1723. PMID: 25632146.

Atasoy et al (2014) A genetically specified connectomics approach applied to long-range feeding regulatory circuits. Nat Neurosci 17 1830. PMID: 25362474.

Atasoy et al (2012) Deconstruction of a neural circuit for hunger. Mol Pain 488 172. PMID: 22801496.

Kramár et al (2009) Cytoskeletal changes underlie estrogen's acute effects on synaptic transmission and plasticity. Cereb Cortex 29 12982. PMID: 19828812.

Ohba et al (2005) BDNF locally potentiates GABAergic presynaptic machineries: target-selective circuit inhibition. Proc Natl Acad Sci U S A 15 291. PMID: 15238431.

Ying and Goldstein (2005) Propofol suppresses synaptic responsiveness of somatosensory relay neurons to excitatory input by potentiating GABA(A) receptor chloride channels. J Neurosci 1 2. PMID: 15813991.

Melyan et al (2004) Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors. J Neurosci 24 4530. PMID: 15140923.

Piet et al (2004) Physiological contribution of the astrocytic environment of neurons to intersynaptic crosstalk. J Neurosci 101 2151. PMID: 14766975.

Wood et al (2000) The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen. J Neurosci 131 1050. PMID: 11082110.

Do you know of a great paper that uses Saclofen from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Saclofen, supplier, Selective, GABAB, antagonists, Receptors, Tocris Bioscience, GABAB Receptor Antagonist products

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