RS 23597-190 hydrochloride
Cat. No. 0728
Chemical Name: 3-(Piperidin-1-yl)propyl 4-amino-5-chloro-2-methoxybenzoate hydrochloride
Biological ActivityA high affinity, selective competitive antagonist at 5-HT4 receptors.
Licensing InformationSold with the permission of Roche Bioscience
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
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References are publications that support the products' biological activity.
Eglen et al (1995) Central 5-HT4 receptors. TiPS 16 391. PMID: 8578609.
Eglen et al (1993) RS 23597-190: a potent and selective 5-HT4 receptor antagonist. Br.J.Pharmacol. 110 119. PMID: 8220871.
If you know of a relevant reference for RS 23597-190 hydrochloride please let us know.
Citations are publications that use Tocris products. Selected citations for RS 23597-190 hydrochloride include:
Huang and Kandel (2007) 5-Hydroxytryptamine induces a protein kinase A/mitogen-activated protein kinase-mediated and macromolecular synthesis-dependent late phase of long-term potentiation in the amygdala. J Pharmacol Exp Ther 27 3111. PMID: 17376972.
Woo et al (2007) Neuregulin-1 enhances depolarization-induced GABA release. Neuron 54 599. PMID: 17521572.
Kato et al (2006) Direct GABAergic and glycinergic inhibition of the substantia gelatinosa from the rostral ventromedial medulla revealed by in vivo patch-clamp analysis in rats. J Neurosci 26 1787. PMID: 16467527.
Do you know of a great paper that uses RS 23597-190 hydrochloride from Tocris? If so please let us know.
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