Rolipram

Cat. No. 0905

Rolipram C16H21NO3 [61413-54-5]

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Chemical Name: 4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one

Biological Activity

Selective inhibitor of cAMP phosphodiesterase (PDE4) (IC50 = 2.0 μM). Discriminates between two conformational states of PDE4 isoenzymes. Separate isomers (R)-(-)-Rolipram and (S)-(+)-Rolipram are available (Cat. Nos. 1349 and 1350 respectively).

Technical Data

M.Wt:
275.35
Formula:
C16H21NO3
Solubility:
Soluble to 75 mM in DMSO and to 75 mM in ethanol
Purity:
>98 %
Storage:
Store at RT
CAS No:
61413-54-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Teixeira et al (1997) Phosphodiesterase (PDE)4 inhibitors: anti-inflammatory drugs of the future? Trends Pharmacol.Sci. 18 164. PMID: 9184477.

Kato et al (1995) Rolipram, a cyclic AMP-selective phosphodiesterase inhibitor, reduces neuronal damage following cerebral ischemia in the gerbil. Eur.J.Pharmacol. 272 107. PMID: 7713141.

O'Donnell (1993) Antidepressant-like effects of rolipram and other inhibitors of cyclic adenosine monophosphate phosphodiesterase on behaviour maintained by differential reinforcement of low response rate. J.Pharmacol.Exp.Ther. 264 1168. PMID: 8383740.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Rolipram include:

Orru et al (2013) Psychostimulant pharmacological profile of paraxanthine, the main metabolite of caffeine in humans. Neuropharmacology 67 476. PMID: 23261866.

Adderley et al (2011) Inhibition of ATP release from erythrocytes: a role for EPACs and PKC. Microcirculation 18 128. PMID: 21166931.

Do you know of a great paper that uses Rolipram from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Rolipram, supplier, PDE4, inhibitors, inhibits, Phosphodiesterases, Tocris Bioscience, Phosphodiesterase Inhibitor products

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