Rolipram

Cat. No. 0905

Rolipram C16H21NO3 [61413-54-5]

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Chemical Name: 4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one

Biological Activity

Selective inhibitor of cAMP phosphodiesterase (PDE4) (IC50 = 2.0 μM). Discriminates between two conformational states of PDE4 isoenzymes. Separate isomers (R)-(-)-Rolipram and (S)-(+)-Rolipram are available (Cat. Nos. 1349 and 1350 respectively).

Technical Data

M.Wt:
275.35
Formula:
C16H21NO3
Solubility:
Soluble to 75 mM in DMSO and to 75 mM in ethanol
Purity:
>98 %
Storage:
Store at RT
CAS No:
61413-54-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Teixeira et al (1997) Phosphodiesterase (PDE)4 inhibitors: anti-inflammatory drugs of the future? Trends Pharmacol.Sci. 18 164. PMID: 9184477.

Kato et al (1995) Rolipram, a cyclic AMP-selective phosphodiesterase inhibitor, reduces neuronal damage following cerebral ischemia in the gerbil. Eur.J.Pharmacol. 272 107. PMID: 7713141.

O'Donnell (1993) Antidepressant-like effects of rolipram and other inhibitors of cyclic adenosine monophosphate phosphodiesterase on behaviour maintained by differential reinforcement of low response rate. J.Pharmacol.Exp.Ther. 264 1168. PMID: 8383740.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Rolipram include:

Ørstavik et al (2015) The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium. J Biol Chem 10 e0115547. PMID: 25738589.

Choi et al (2015) PDE-4 inhibition rescues aberrant synaptic plasticity in Drosophila and mouse models of fragile X syndrome. Pharmacol Res Perspect 35 396. PMID: 25568131.

Merino et al (2015) Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with Isoproterenol. PLoS One 10 e0132884. PMID: 26222156.

Parnell et al (2015) Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells. Eneuro 1853 1749. PMID: 25913012.

Pecha et al (2015) β 1 Adrenoceptor antagonistic effects of the supposedly selective β 2 adrenoceptor antagonist ICI 118,551 on the positive inotropic effect of adrenaline in murine hearts. PLoS One 3 e00168. PMID: 26516580.

Polito et al (2015) Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3). J Neurosci 2. PMID: 26465004.

Zhu et al (2015) Different patterns of electrical activity lead to long-term potentiation by activating different intracellular pathways. J Neurosci 35 621. PMID: 25589756.

Orru et al (2013) Psychostimulant pharmacological profile of paraxanthine, the main metabolite of caffeine in humans. Neuropharmacology 67 476. PMID: 23261866.

Adderley et al (2011) Inhibition of ATP release from erythrocytes: a role for EPACs and PKC. Microcirculation 18 128. PMID: 21166931.

Morales-Garcia et al (2011) Phosphodiesterase 7 inhibition preserves dopaminergic neurons in cellular and rodent models of Parkinson disease. PLoS One 6 e17240. PMID: 21390306.

Schapitz et al (2010) Neuroligin 1 is dynamically exchanged at postsynaptic sites. Biochim Biophys Acta 30 12733. PMID: 20861378.

Hosoi et al (2002) Identification of a novel human eicosanoid receptor coupled to G(i/o). J Pharmacol Exp Ther 277 31459. PMID: 12065583.

Do you know of a great paper that uses Rolipram from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Rolipram, supplier, PDE4, inhibitors, inhibits, Phosphodiesterases, Tocris Bioscience, Phosphodiesterase Inhibitor products

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