Cat. No. 0415
Chemical Name: 4-(3-Butoxy-4-methoxyphenyl)methyl-
Biological ActivityWidely used inhibitor of cyclic nucleotide phosphodiesterase, selective for PDE4 (IC50 = 2.0 μM). Also available as part of the Phosphodiesterase Inhibitor Tocriset™.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Soderling et al (1998) Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase. Proc.Natl.Acad.Sci.U.S.A. 95 8991. PMID: 9671792.
Nicholson et al (1991) Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes. TiPS 12 19. PMID: 1848733.
Reeves et al (1987) The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Biochem.J. 241 535. PMID: 3036066.
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Citations are publications that use Tocris products. Selected citations for Ro 20-1724 include:
Winger et al (2014) Rapid remodeling of tight junctions during paracellular diapedesis in a human model of the blood-brain barrier. J Immunol 193 2427. PMID: 25063869.
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Keywords: Ro 20-1724, supplier, PDE4, inhibitors, inhibits, Phosphodiesterases, Ro20-1724, Tocris Bioscience, Phosphodiesterase Inhibitor products
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