Riluzole hydrochloride

Cat. No. 0768

Riluzole hydrochloride C8H5F3N2OS.HCl [850608-87-6]

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Chemical Name: 2-Amino-6-trifluoromethoxybenzothiazole hydrochloride

Biological Activity

Psychotropic agent with anticonvulsant, hypnotic, anxiolytic, anti-ischemic and anesthetic properties. Inhibits glutamate release from presynaptic terminals and increases Na+-dependent glutamate uptake in rat cortical synaptosomes. Blocks voltage-dependent Na+ channels and inhibits GABA uptake by striatal synaptosomes; neuroprotective.

Technical Data

M.Wt:
270.66
Formula:
C8H5F3N2OS.HCl
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in water with gentle warming
Purity:
>98 %
Storage:
Store at RT
CAS No:
850608-87-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Fumagalli et al (2008) Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1. Eur.J.Pharmacol. 578 171. PMID: 18036519.

Song et al (1997) Differential action of riluzole on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels. J.Pharmacol.Exp.Ther. 282 707. PMID: 9262334.

Taylor and Meldrum (1995) Na+ channels as targets for neuroprotective drugs. TiPS 16 309. PMID: 7482996.

Umeniya and Berger (1995) Inhibition by riluzole of glycinergic postsynaptic currents in rat hypoglossal motoneurones. Br.J.Pharmacol. 116 3227. PMID: 8719800.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Riluzole hydrochloride include:

Du et al (2015) Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells. Nat Commun 6 6626. PMID: 25806427.

Veettil et al (2014) Glutamate secretion and metabotropic glutamate receptor 1 expression during Kaposi's sarcoma-associated herpesvirus infection promotes cell proliferation. PLoS Pathog 10 e1004389. PMID: 25299066.

Le et al (2010) The glutamate release inhibitor Riluzole decreases migration, invasion, and proliferation of melanoma cells. J Invest Dermatol 130 2240. PMID: 20505744.

Morgado-Valle et al (2010) Glycinergic pacemaker neurons in preBötzinger complex of neonatal mouse. J Neurosci 30 3634. PMID: 20219997.

Do you know of a great paper that uses Riluzole hydrochloride from Tocris? If so please let us know.show all ▼show less ▲

View Related Products by Product Action

Keywords: Riluzole hydrochloride, supplier, Glutamate, release, inhibitors, inhibits, GABA, uptake, Na+, channel, blockers, glutamate, mGlur, Receptors, Metabotropic, Sodium, NaV, Channels, voltage-gated, voltage-dependent, iGlu, Ionotropic, BGT-1, GAT, Transporters, Monoamine, Neurotransmitter, neuroprotective, Tocris Bioscience, Miscellaneous Glutamate Inhibitor products

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