Cat. No. 0768
Chemical Name: 2-Amino-6-trifluoromethoxybenzothia
Biological ActivityPsychotropic agent with anticonvulsant, hypnotic, anxiolytic, anti-ischemic and anesthetic properties. Inhibits glutamate release from presynaptic terminals and increases Na+-dependent glutamate uptake in rat cortical synaptosomes. Blocks voltage-dependent Na+ channels and inhibits GABA uptake by striatal synaptosomes; neuroprotective.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Fumagalli et al (2008) Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1. Eur.J.Pharmacol. 578 171. PMID: 18036519.
Song et al (1997) Differential action of riluzole on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels. J.Pharmacol.Exp.Ther. 282 707. PMID: 9262334.
Taylor and Meldrum (1995) Na+ channels as targets for neuroprotective drugs. TiPS 16 309. PMID: 7482996.
Umeniya and Berger (1995) Inhibition by riluzole of glycinergic postsynaptic currents in rat hypoglossal motoneurones. Br.J.Pharmacol. 116 3227. PMID: 8719800.
If you know of a relevant reference for Riluzole hydrochloride please let us know.
Citations are publications that use Tocris products. Selected citations for Riluzole hydrochloride include:
Du et al (2015) Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells. Nat Commun 6 6626. PMID: 25806427.
Du et al (2015) Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells. Nat.Commun. 6 6626. PMID: 25806427.
Rosenberg et al (2015) Targeting Glutamatergic Signaling and the PI3 Kinase Pathway to Halt Melanoma Progression. Front Neural Circuits 8 42614. PMID: 25749171.
Veettil et al (2014) Glutamate secretion and metabotropic glutamate receptor 1 expression during Kaposi's sarcoma-associated herpesvirus infection promotes cell proliferation. PLoS Pathog 10 e1004389. PMID: 25299066.
Viemari et al (2013) β-Noradrenergic receptor activation specifically modulates the generation of sighs in vivo and in vitro. Neurochem Int 7 179. PMID: 24273495.
Carbone et al (2012) Riluzole elevates GLT-1 activity and levels in striatal astrocytes. BMC Neurosci 60 42613. PMID: 22080156.
Carbone et al (2012) Riluzole neuroprotection in a Parkinson's disease model involves suppression of reactive astrocytosis but not GLT-1 regulation. Cells 13 38. PMID: 22480308.
Le et al (2010) The glutamate release inhibitor Riluzole decreases migration, invasion, and proliferation of melanoma cells. J Invest Dermatol 130 2240. PMID: 20505744.
Morgado-Valle et al (2010) Glycinergic pacemaker neurons in preBötzinger complex of neonatal mouse. J Neurosci 30 3634. PMID: 20219997.
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Keywords: Riluzole hydrochloride, supplier, Glutamate, release, inhibitors, inhibits, GABA, uptake, Na+, channel, blockers, glutamate, mGlur, Receptors, Metabotropic, Sodium, NaV, Channels, voltage-gated, voltage-dependent, iGlu, Ionotropic, BGT-1, GAT, Transporters, Monoamine, Neurotransmitter, neuroprotective, Tocris Bioscience, GABA Inhibitor products