Cat. No. 0790
Chemical Name: 2-[N-(Dicyclopropylmethyl)amino]oxa
Biological ActivityI1-imidazoline binding site selective ligand and α2-adrenoceptor agonist. Possesses greater I1 vs α2 selectivity than the prototypical compound, clonidine. Also thought to enhance autophagy; shown to increase LC3-II levels in PC12 cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Williams et al (2008) Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nat.Chem.Biol. 4 295. PMID: 18391949.
Mammoto et al (1996) Antiarrhythmic action of rilmenidine on adrenaline-induced arrhythmia via central imidazoline receptors in halothane-anaesthetized dogs. Br.J.Pharmacol. 117 1744. PMID: 8732285.
Bricca et al (1994) Human brain imidazoline receptors: Further characterisation with [3H] clonidine. Eur.J.Pharmacol. 266 25. PMID: 8137880.
Michel and Ernsberger (1992) Keeping an eye on the I site: imidazoline-preferring receptors. TiPS 13 369. PMID: 1413085.
Bricca et al (1989) Rilmenidine selectivity for imidazoline receptors in human brain. Eur.J.Pharmacol. 163 373. PMID: 2566507.
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Citations are publications that use Tocris products. Selected citations for Rilmenidine hemifumarate include:
Sánchez-Blázquez et al (2000) Activation of I(2)-imidazoline receptors enhances supraspinal morphine analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br J Pharmacol 130 146. PMID: 10781010.
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Keywords: Rilmenidine hemifumarate, supplier, α2-adrenoceptor, alpha2-adrenoceptor, a2-adrenoceptor, α2-Adrenergic, alpha2-Adrenergic, a2-adrenergic, agonists, I1, ligand, Receptors, Imidazoline, Tocris Bioscience, Adrenergic α2 Receptor Agonist products
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Selective, high affinity, non-competitive α1A adrenoceptor antagonist
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