Remoxipride hydrochloride

Cat. No. 0916

Remoxipride hydrochloride C16H23BrN2O3.HCl [73220-03-8]

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Chemical Name: (S)-(-)-3-Bromo-N-[(1-ethyl-2-pyrrolidinylmethyl]2,6-dimethoxybenzamide hydrochloride

Biological Activity

Dopamine D2 receptor antagonist showing selectivity over D3 and D4 receptors (Ki values are ~ 300, ~ 1600, and ~ 2800 nM for D2, D3 and D4 receptors respectively). Exhibits antipsychotic activity in vivo with no extrapyramidal side effects. 50-fold more potent than sulpiride in antagonising the effects of apomorphine in the rat.

Technical Data

M.Wt:
407.73
Formula:
C16H23BrN2O3.HCl
Solubility:
Soluble to 100 mM in water
Storage:
Store at RT
CAS No:
73220-03-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Ahlenius et al (1997) In vivo effects of remoxipride and aromatic ring metabolites in the rat. J.Pharmacol.Exp.Ther. 283 1356. PMID: 9400011.

Seeman and Van Tol (1994) Dopamine receptor pharmacology. TiPS 15 264. PMID: 7940991.

Mohell et al (1993) Binding characteristics of remoxipride and its metabolites to dopamine D2 and D3 receptors. Eur.J.Pharmacol. 238 121. PMID: 8405075.

Sedvall (1990) Development of a new antipsychotic remoxipride. Acta Psychiatr.Scand.Suppl. 358 1. PMID: 1978466.

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Keywords: Remoxipride hydrochloride, supplier, selective, D2-like, antagonists, dopamine, non-selective, receptor, antagonist, dopaminergic, d2, Tocris Bioscience, Non-selective Dopamine Antagonist products

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