Rauwolscine hydrochloride

Cat. No. 0891

Rauwolscine hydrochloride
 C21H26N2O3.HCl [6211-32-1]

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Alternative Names: α-Yohimbine hydrochloride, Corynanthidine

Chemical Name: 17α-Hydroxy-20α-yohimban-16β-carboxylic acid,methyl ester hydrochloride

Biological Activity

Standard α2-adrenergic antagonist (Ki values are 3.5, 4.6, and 0.6 nM at cloned human α2A, α2B, and α2C-adrenoceptors respectively). Partial agonist at 5-HT1A receptors. Also available as part of the α2-Adrenoceptor Tocriset™. Diastereomer Yohimbine hydrochloride (Cat. No. 1127) also available.

Technical Data

M.Wt:
390.91
Formula:
C21H26N2O3.HCl
Solubility:
Soluble to 5 mM in water with gentle warming and to 25 mM in DMSO with gentle warming
Purity:
>95 %
Storage:
Store at RT
CAS No:
6211-32-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Uhlen et al (1998) [3H]RS79948-197 binding to human, rat, guinea pig and pig α2A-, α2B-, and α2C-adrenoceptors. Comparison with MK912, RX821002, rauwolscine and yohimbine. Eur.J.Pharmacol. 343 93. PMID: 9551719.

Hieble et al (1995) β- and γ-Adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. J.Med.Chem. 38 3415. PMID: 7658428.

Arthur et al (1993) Partial agonist properties of rauwolscine and yohimbine for the inhibition of adenylyl cyclase by recombinant human 5-HT1A receptors. Biochem.Pharmacol. 45 2337. PMID: 8517875.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Rauwolscine hydrochloride include:

Moura et al (2006) Alpha2-adrenoceptor subtypes involved in the regulation of catecholamine release from the adrenal medulla of mice. Br J Pharmacol 149 1049. PMID: 17075569.

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