L-Quisqualic acid

Cat. No. 0188

L-Quisqualic acid C5H7N3O5 [52809-07-1]

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Chemical Name: (L)-(+)-α-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic acid

Biological Activity

Glutamate receptor agonist acting at AMPA receptors and metabotropic glutamate receptors positively linked to phosphoinositide hydrolysis. Sensitizes neurons in hippocampus to depolarization by L-AP6 (the so called 'quis' effect). Also available as part of the Group I mGlu Receptor Tocriset™.

Technical Data

M.Wt:
189.13
Formula:
C5H7N3O5
Solubility:
Soluble to 100 mM in 1eq. NaOH and to 10 mM in water
Purity:
>99 %
Storage:
Store at RT
CAS No:
52809-07-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Littman et al (1995) Effects of quisqualic acid analogs on metabotropic glutamate receptors coupled to phosphoinositide hydrolysis in rat hippocampus. Neuropharmacology 34 829. PMID: 8532164.

Schulte et al (1994) Utilization of the resolved L-isomer of 2-amino-6-phosphohexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons. Brain Res. 649 203. PMID: 7953634.

Porter et al (1992) (S)-Homoquisqualate: a potent agonist at the glutamate metabotropic receptor. Br.J.Pharmacol. 106 509. PMID: 1324071.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for L-Quisqualic acid include:

Hu and Tu (2015) The roads to mitochondrial dysfunction in a rat model of posttraumatic syringomyelia. Biomed Res Int 2015 831490. PMID: 25685811.

Mansari et al (2015) Effects of acute and sustained administration of vortioxetine on the serotonin system in the hippocampus: electrophysiological studies in the rat brain. Psychopharmacology (Berl) 232 2343. PMID: 25665528.

Mansari et al (2015) Restoration of serotonin neuronal firing following long-term administration of bupropion but not paroxetine in olfactory bulbectomized rats. Int J Neuropsychopharmacol 18. PMID: 25522394.

Wall et al (2014) Disruption of GRM1-mediated signalling using riluzole results in DNA damage in melanoma cells. Pigment Cell Melanoma Res 27 263. PMID: 24330389.

Calò et al (2005) Interactions between ephrin-B and metabotropic glutamate 1 receptors in brain tissue and cultured neurons. J Neurosci 25 2245. PMID: 15745950.

Porter et al (2005) Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity. J Pharmacol Exp Ther 315 711. PMID: 16040814.

Ferré et al (2002) Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function. Proc Natl Acad Sci U S A 99 11940. PMID: 12189203.

Do you know of a great paper that uses L-Quisqualic acid from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: L-Quisqualic acid, supplier, AMPA, group, I, mGlur, agonists, potent, Glutamate, Receptors, iGlur, Ionotropic, Group, mGlu1, mGlu5, mGluR1, mGluR5, Metabotropic, Tocris Bioscience, AMPA Receptor Agonist products

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