Cat. No. 0629
Chemical Name: 2-(1-Piperazinyl)quinoline dimaleate
Biological ActivitySelective 5-HT3 receptor agonist. Also displays antagonist activity at peripheral 5-HT3 receptors. [3H]-Quipazine labels 5-HT3 sites in the cortical membranes.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Sharif et al (1991) Characteristics of 5-HT3 binding sites in NG108-15, NCB-20 neuroblastoma cells and rat cerebral cortex using [3H]-quipazine and [3H]-GR65630 binding. Br.J.Pharmacol. 102 919. PMID: 1830236.
Peroutka and Hamik (1988) [3H]Quipazine labels 5-HT3 recognition sites in rat cortical membranes. Eur.J.Pharmacol. 148 297. PMID: 3378579.
Ireland and Tyers (1987) Pharmacological characterization of 5-hydroxytryptamine-induced depolarization of the rat isolated vagus nerve. Br.J.Pharmacol. 90 229. PMID: 3814920.
If you know of a relevant reference for Quipazine dimaleate please let us know.
Citations are publications that use Tocris products. Selected citations for Quipazine dimaleate include:
Hutchinson et al (2012) Differential regulation of MeCP2 phosphorylation in the CNS by dopamine and serotonin. Br J Pharmacol 37 321. PMID: 21956448.
Do you know of a great paper that uses Quipazine dimaleate from Tocris? If so please let us know.
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Keywords: Quipazine dimaleate, supplier, 5-HT3, agonists, Serotonin, Receptors, Tocris Bioscience, 5-HT3 Receptor Agonist products
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June 14 - 17, 2017
Boston, MA, USA