Cat. No. 0225
Chemical Name: Pyridine-2,3-dicarboxylic acid
Biological ActivityEndogenous NMDA agonist and transmitter candidate. May distinguish between NMDA receptor subtypes.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Prada de Carvalho et al (1996) The endogenous agonist quinolinic acid and the non-endogenous homoquinolinic acid discriminate between NMDAR2 receptor subunits. Neurochem.Int. 28 445. PMID: 8740453.
Monaghan and Beaton (1991) Quinolinate differentiates between forebrain and cerebellar NMDA receptors. Eur.J.Pharmacol. 194 123. PMID: 1676371.
Stone and Burton (1988) NMDA receptors and ligands in the vertebrate CNS. Prog.Neurobiol. 30 333. PMID: 2830636.
Stone and Perkins (1981) Quinolinic acid: a potent endogenous excitant at amino acid receptors in the rat CNS. Eur.J.Pharmacol. 72 411. PMID: 6268428.
If you know of a relevant reference for Quinolinic acid please let us know.
Citations are publications that use Tocris products. Selected citations for Quinolinic acid include:
Tsutsui-Kimura et al (2015) Milnacipran remediates impulsive deficits in rats with lesions of the ventromedial prefrontal cortex. Nat Commun 18. PMID: 25522418.
Do you know of a great paper that uses Quinolinic acid from Tocris? If so please let us know.
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Keywords: Quinolinic acid, supplier, agonists, Transmitter, candidate, Glutamate, NMDA, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, Tocris Bioscience, NMDA Receptor Agonist products
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