Propranolol hydrochloride

Cat. No. 0624

Propranolol hydrochloride C16H21NO2.HCl [3506-09-0]

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Chemical Name: (RS)-1-[(1-Methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol hydrochloride

Biological Activity

β-adrenergic antagonist. Separate isomers (S)-(-)-Propranolol hydrochloride and (R)-(+)-Propranolol hydrochloride also available (Cat. No's. 0834 and 0835 respectively).

Technical Data

M.Wt:
295.81
Formula:
C16H21NO2.HCl
Solubility:
Soluble to 100 mM in water
Storage:
Store at RT
CAS No:
3506-09-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Litwin et al (1999) Effects of propranolol treatment on left ventricular function and intracellular calcium regulation in rats with postinfarction heart failure. Br.J.Pharmacol. 127 1671. PMID: 10455325.

Xie et al (1998) The inhibitory effect of propranolol on ATP-sensitive potassium channels in neonatal rat heart. Br.J.Pharmacol. 123 599. PMID: 9517376.

Merck Index 12 8025.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Propranolol hydrochloride include:

Gherbi et al (2015) Negative cooperativity across β1-adrenoceptor homodimers provides insights into the nature of the secondary low-affinity CGP 12177 β1-adrenoceptor binding conformation. FASEB J 29 2859. PMID: 25837585.

Hansen and Manahan-Vaughan (2015) Locus Coeruleus Stimulation Facilitates Long-Term Depression in the Dentate Gyrus That Requires Activation of β-Adrenergic Receptors. Mol Cancer 25 1889. PMID: 24464942.

Patsouris et al (2015) Burn Induces Browning of the Subcutaneous White Adipose Tissue in Mice and Humans. Cereb Cortex 13 1538. PMID: 26586436.

Stoddart et al (2015) Application of BRET to monitor ligand binding to GPCRs. Nat Methods 12 661. PMID: 26030448.

Bucher et al (2014) Medullary norepinephrine neurons modulate local oxygen concentrations in the bed nucleus of the stria terminalis. J Cereb Blood Flow Metab 34 1128. PMID: 24714037.

Gherbi et al (2014) Detection of the secondary, low-affinity β1 -adrenoceptor site in living cells using the fluorescent CGP 12177 derivative BODIPY-TMR-CGP. Br J Pharmacol 171 5431. PMID: 25052258.

Meitzen et al (2011) β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem 116 984. PMID: 21143600.

Rankovic et al (2011) Modulation of calcium-dependent inactivation of L-type Ca2+ channels via β-adrenergic signaling in thalamocortical relay neurons. PLoS One 6 e27474. PMID: 22164209.

Shi et al (2010) Catecholamine up-regulates MMP-7 expression by activating AP-1 and STAT3 in gastric cancer. Purinergic Signal 9 269. PMID: 20939893.

Do you know of a great paper that uses Propranolol hydrochloride from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Propranolol hydrochloride, supplier, β-adrenoceptor, beta-adrenoceptors, b-adrenoceptors, b-adrenergic, antagonists, β-adrenergic, beta-adrenergic, Receptors, Non-Selective, β-blockers, beta-blockers, Tocris Bioscience, Non-selective Adrenergic β Receptor Antagonist products

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