RJR 2403 oxalate

Cat. No. 1053

RJR 2403 oxalate C10H14N2.C2H2O4 [220662-95-3]

Price and Availability

For RJR 2403 oxalate pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Names: Metanicotine, TC-2403

Chemical Name: (E)-N-Methyl-4-(3-pyridinyl)-3-buten-1-amine oxalate

Biological Activity

A neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki values are 26 and 36000 nM for α4β2 and α7 receptors respectively). Active in vivo.

Technical Data

M.Wt:
252.27
Formula:
C10H14N2.C2H2O4
Solubility:
Soluble to 100 mM in water
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
220662-95-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Damaj et al (1999) Antinociceptive and pharmacological effects of metanicotine, a selective nicotinic agonist. J.Pharmacol.Exp.Ther. 291 390. PMID: 10490929.

Bencherif et al (1996) RJR-2403: a nicotinic agonist with CNS selectivity I. In vitro characterization. J.Pharmacol.Exp.Ther. 279 1413. PMID: 8968366.

Lippiello et al (1996) RJR-2403: a nicotinic agonist with CNS selectivity II. In vivo characterization. J.Pharmacol.Exp.Ther. 279 1422. PMID: 8968367.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for RJR 2403 oxalate include:

Kiss et al (2014) Nicotinic acetylcholine receptors containing the α7-like subunit mediate contractions of muscles responsible for space positioning of the snail, Helix pomatia L. tentacle. PLoS One 9 e109538. PMID: 25303328.

Zhong et al (2013) Nicotine elicits prolonged calcium signaling along ventral hippocampal axons. Dev Neurobiol 8 e82719. PMID: 24349346.

Scholze et al (2011) α4β2 nicotinic acetylcholine receptors in the early postnatal mouse superior cervical ganglion. Cardiovasc Res 71 390. PMID: 21485013.

Zakharova et al (2011) Chronic cerebral ischaemia forms new cholinergic mechanisms of learning and memory. Int J Alzheimers Dis 2010 954589. PMID: 21197444.

Li et al (2009) Specific subtypes of nicotinic cholinergic receptors involved in sympathetic and parasympathetic cardiovascular responses. Neurosci Lett 462 20. PMID: 19573576.

Liu et al (2009) A novel nicotinic acetylcholine receptor subtype in basal forebrain cholinergic neurons with high sensitivity to amyloid peptides. J Neurosci 29 918. PMID: 19176801.

Do you know of a great paper that uses RJR 2403 oxalate from Tocris? If so please let us know.show all ▼show less ▲

View Related Products by Target

View Related Products by Product Action

Keywords: RJR 2403 oxalate, supplier, α4β2, selective, nicotinic, agonists, a4b2, Nicotinic, Receptors, Acetylcholine, nAChR, RJR2403, oxalate, Tocris Bioscience, Nicotinic (α4β2) Receptor Agonist products

Quick Order

Find multiple products by catalog number

divider line

Pain Research Product Guide

Pain Research Product Guide

Our Pain guide highlights over 280 products for Pain research. Request copy or view PDF today.

divider line

Neurodegeneration Research Product Guide

Neurodegeneration Product Guide

Our Neurodegeneration guide highlights over 275 products for neurodegeneration research. Request copy or view PDF today.

divider line

Nicotinic ACh Review

Written by Susan Wonnacott

Nicotinic ACh Receptors Scientific Review

Our Nicotinic Acetylcholine Receptor review summarizes the structure and function of nAChR receptors, and the pharmacological ligands used to study them. Request copy or view PDF today.

divider line

Alzheimer's Disease: Neurobiology and Drug Targets

Written by Alan Palmer

Alzheimer's Life Science Poster

Our Alzheimer's disease poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease. Request copy or view PDF today.

divider line

Peripheral Sensitization

Written by Grant D. Nicol and Michael R. Vasko

Pain Life Science Poster

Our Peripheral Sensitization poster gives a summary of the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. Request copy or view PDF today.

divider line

Bio-Techne Events

One Day Symposium

Bio-Techne Symposium 2017

Epigenetic Regulation of Stem Cell Differentiation

March 1, 2017

Amsterdam, The Netherlands