Prazosin hydrochloride

Cat. No. 0623

Prazosin hydrochloride C19H21N5O4.HCl [19237-84-4]

Price and Availability

For Prazosin hydrochloride pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride

Biological Activity

α1 and α2B-adrenoceptor antagonist. Also a potent antagonist at the melatonin MT3 receptor (Ki = 10.2 nM). Also available as part of the α1-Adrenoceptor Tocriset™ and Mixed Adrenergic Tocriset™.

Technical Data

M.Wt:
419.87
Formula:
C19H21N5O4.HCl
Solubility:
Soluble to 25 mM in DMSO and to 5 mM in ethanol
Purity:
>99 %
Storage:
Store at RT
CAS No:
19237-84-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
Select another batch:

Paul et al (1999) Characterisation of 2-[125I]iodomelatonin binding sites in syrian hamster peripheral organs. J.Pharmacol.Exp.Ther. 290 334. PMID: 10381796.

Mathe et al (1996) Prazosin inhibits MK-801-induced hyperlocomotion and dopamine release in the nucleus accumbens. Eur.J.Pharmacol. 309 1. PMID: 8864686.

Pickering and Niles (1990) Pharmacological characterization of melatonin binding sites in Syrian hamster hypothalamus. Eur.J.Pharmacol. 175 71. PMID: 2157597.

Merck Index 12 7897.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Prazosin hydrochloride include:

Delaney and Crane (2016) Presynaptic GABAB receptors reduce transmission at parabrachial synapses in the lateral central amygdala by inhibiting N-type calcium channels. Sci Rep 6 19255. PMID: 26755335.

Corcoran et al (2014) Dual effects of 5-HT(1a) receptor activation on breathing in neonatal mice. Pain 34 51. PMID: 24381267.

Hughes et al (2013) Endogenous analgesic action of the pontospinal noradrenergic system spatially restricts and temporally delays the progression of neuropathic pain following tibial nerve injury. J Clin Invest 154 1680. PMID: 23707289.

Tjen-A-Looi et al (2011) Central and peripheral mechanisms underlying gastric distention inhibitory reflex responses in hypercapnic-acidotic rats. Am J Physiol Heart Circ Physiol 300 H1003. PMID: 21217073.

Zemkova et al (2011) Norepinephrine causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+. Endocrinology 152 3842. PMID: 21828176.

Ajmo et al (2009) Blockade of adrenoreceptors inhibits the splenic response to stroke. Cell Rep 218 47. PMID: 19371742.

Moura et al (2006) Alpha2-adrenoceptor subtypes involved in the regulation of catecholamine release from the adrenal medulla of mice. Br J Pharmacol 149 1049. PMID: 17075569.

Sjöblom et al (2001) Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion. Exp Neurol 108 625. PMID: 11518737.

Do you know of a great paper that uses Prazosin hydrochloride from Tocris? If so please let us know.show all ▼show less ▲

View Related Products by Product Action

Keywords: Prazosin hydrochloride, supplier, α1-adrenoceptor, alpha1-adrenoceptor, a1-adrenoceptor, antagonists, MT3, α1-adrenergic, alpha1-adrenergic, a1-adrenergic, Receptors, MT, Melatonin, Tocris Bioscience, Adrenergic α1 Receptor Antagonist products

Quick Order

Find multiple products by catalog number

divider line

Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

Our Cardiovascular Guide highlights over 250 products for cardiovascular research. Request copy or view PDF today.

divider line

GPCR Product Listing

GPCR Product Listing

Highlights over 450 products for GPCRs. Request copy or view PDF today.

divider line

Regulation of Vascular Reactivity by GPCRs

Written by J.J. Maguire and A.P. Davenport

Cardiovascular Life Science Poster

Our Cardiovascular poster highlights the key G protein-coupled receptors involved in the regulation of vascular reactivity. Request copy today.

divider line

Antidepressants - Current and Future Targets

Written by P. Skolnich et al

Depression Life Science Poster

Our Depression poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder. Request copy or view PDF today.

divider line

New Products in this Area

AdTx1

Selective, high affinity, non-competitive α1A adrenoceptor antagonist

Sign-up for new product e-alerts
divider line

Bio-Techne Events

One Day Symposium

Bio-Techne Symposium 2017

Epigenetic Regulation of Stem Cell Differentiation

March 1, 2017

Amsterdam, The Netherlands