Prazosin hydrochloride

Cat. No. 0623

Prazosin hydrochloride C19H21N5O4.HCl [19237-84-4]

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Chemical Name: 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride

Biological Activity

α1 and α2B-adrenoceptor antagonist. Also a potent antagonist at the melatonin MT3 receptor (Ki = 10.2 nM). Also available as part of the α1-Adrenoceptor Tocriset™ and Mixed Adrenergic Tocriset™.

Technical Data

M.Wt:
419.87
Formula:
C19H21N5O4.HCl
Solubility:
Soluble to 25 mM in DMSO and to 5 mM in ethanol
Purity:
>99 %
Storage:
Store at RT
CAS No:
19237-84-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Paul et al (1999) Characterisation of 2-[125I]iodomelatonin binding sites in syrian hamster peripheral organs. J.Pharmacol.Exp.Ther. 290 334. PMID: 10381796.

Mathe et al (1996) Prazosin inhibits MK-801-induced hyperlocomotion and dopamine release in the nucleus accumbens. Eur.J.Pharmacol. 309 1. PMID: 8864686.

Pickering and Niles (1990) Pharmacological characterization of melatonin binding sites in Syrian hamster hypothalamus. Eur.J.Pharmacol. 175 71. PMID: 2157597.

Merck Index 12 7897.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Prazosin hydrochloride include:

Delaney and Crane (2016) Presynaptic GABAB receptors reduce transmission at parabrachial synapses in the lateral central amygdala by inhibiting N-type calcium channels. Sci Rep 6 19255. PMID: 26755335.

Tjen-A-Looi et al (2011) Central and peripheral mechanisms underlying gastric distention inhibitory reflex responses in hypercapnic-acidotic rats. Am J Physiol Heart Circ Physiol 300 H1003. PMID: 21217073.

Zemkova et al (2011) Norepinephrine causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+. Endocrinology 152 3842. PMID: 21828176.

Moura et al (2006) Alpha2-adrenoceptor subtypes involved in the regulation of catecholamine release from the adrenal medulla of mice. Br J Pharmacol 149 1049. PMID: 17075569.

Do you know of a great paper that uses Prazosin hydrochloride from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Prazosin hydrochloride, supplier, α1-adrenoceptor, alpha1-adrenoceptor, a1-adrenoceptor, antagonists, MT3, α1-adrenergic, alpha1-adrenergic, a1-adrenergic, Receptors, MT, Melatonin, Tocris Bioscience, Adrenergic α1 Receptor Antagonist products

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